Fertility and sterility

In this study the immunohistochemical expression of matrix metalloproteinases 1, 2, 3, and 9, tissue inhibitors (TIMPs) 1 and 2, and cathepsin-D in ovarian endometriomas were correlated with the clinical severity of endometriosis (i.e., pre…

The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodul…

Compared with normal endometrium, SLIT expression was statistically significantly higher in ectopic endometrium from women with adenomyosis, while roundabout 1 (ROBO1) immunoreactivity and microvessel density (MVD) level were statistically …

Based on the findings of several reports that have shown an increased plasma level of di-(2-ethylhexyl) phthalate (DEHP) in women with endometriosis, the present study was designed to evaluate whether in vitro treatment with DEHP can increa…

The use of anti-L1-cell adhesion molecule monoclonal antibodies (anti-L1CAM-mAb) in an endometriosis epithelial cell line Z12 led to a statistically significant decrease in cell proliferation and cell invasion and to an inhibition of the ad…

OBJECTIVE: To determine whether nerve fibers can be detected in the endometrium and myometrium in women with painful uterine fibroids and adenomyosis. DESIGN: A retrospective immunohistochemical study. SETTING: An academic training hospit…

OBJECTIVE: To evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis. DESIGN: A literature search was conducted in PubMed to identify all relevant citations. RESULT(S): Our findings highlight the important rol…

This prospective study aimed to evaluate the suitability of the Endometriosis Health Profile-30 Questionnaire (EHP-30) as a self-report health status instrument. We compared our results with those from the U.K. and the U.S. and discovered r…

OBJECTIVE: To present our initial experience in laparoscopic surgery for benign adnexal disease performed exclusively through an umbilical incision using a single three-channel port and flexible laparoscopic instrumentation. DESIGN: Case r…

OBJECTIVE: To describe and evaluate a new technique of laparoscopic treatment of endometriomas that combines excisional and ablative surgery. DESIGN: Descriptive and prospective study. SETTING: Gynecology research unit in a university hos…

OBJECTIVE: To report our experience with endopelvic causes for sacral radiculopathies and sciatica. DESIGN: Prospective cohort study. SETTING: Tertiary referral advanced laparoscopic gynecology and neuropelveologic unit. PATIENT(S): Two …

OBJECTIVE: To study whether an injury-induced inflammation might be the mechanism underlying the favorable effect of endometrial biopsy on the implantation rate in in vitro fertilization (IVF) patients. DESIGN: Controlled clinical study. …

OBJECTIVE: To report on chronic urinary retention after surgery for deep endometriosis and the possible risk factors for this complication. DESIGN: Descriptive study. SETTING: University hospital. PATIENT(S): Four patients with deep endo…

This study analyzed by immunofluorescence staining the sympathetic innervation in the bowel adjacent to the endometriotic lesion and in the healthy tissue at the border of the resected specimen. Sympathetic nerve fibers are significantly re…

OBJECTIVE: To illustrate magnetic resonance neurography findings of severe sciatic injury and muscle denervation related to deep gluteal endometriosis at the sciatic notch. DESIGN: Case report. SETTING: Academic teaching hospital. PATIEN…

The serum concentrations of mannose-binding lectin in patients with or without endometriosis do not differ. Mannose-binding lectin could be involved in the modulation of inflammatory responses, but it does not seem to take part in endometri…

OBJECTIVE: To investigate the role of matrix metalloproteinase 1 and 2 (MMP-1/MMP-2) in human endometrial explants in a chicken chorioallantoic membrane model (CAM) of endometriosis. DESIGN: Experimental prospective study. SETTING: Univer…

In a prospective, blinded, longitudinal study MMP-2, MMP-9, and MMP-9/neutrophil gelatinase-associated lipocalin were significantly more likely to be detected in the urine of patients with endometriosis than in controls.

OBJECTIVE: To compare the expression of MMP-2, TIMP-2, and TGFbeta2 mRNA in experimental and human endometriotic lesions and to assess the possibility of its cytokine regulation. DESIGN: Experimental laboratory study. SETTING: Medical cen…

OBJECTIVE: To examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis. DESIGN: Prospective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endomet…

N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive,…

Ovarian endometriomas (n = 29) were innervated by mainly sympathetic and sensory fibers. These fibers may be involved in the generation of pain symptoms.

OBJECTIVE: To describe a novel use for a tracheobronchial stent to maintain patency after vaginal septum excision in a patient with an obstructed hemivagina and uterine didelphys. DESIGN: Description of a novel technique. SETTING: Univers…

OBJECTIVE: To assess the indications, safety, utilization, and success of ovarian tissue freezing and transplantation. DESIGN: Prospective longitudinal analysis. SETTING: Academic medical centers. PATIENT(S): Fifty-nine women who underwe…