Zentralblatt für Gynäkologie

The pathogenesis of endometriosis is dependent on implantation. Therefore, angiogenesis of the ectopic endometrium is discussed as a crucial step in the development of an endometriotic lesion. It is not only the main condition for implantat…

Endometriosis is an estrogen-dependent and chronic disease with an unknown etiology and pathogenesis. It is however likely and well accepted that retrograde menstruation of endometrial cells into the pelvic cavity is the origin of this dise…

Malignant tumors arising from endometriosis are rare. A frequency of about 1% has been reported with in 80% the ovary, and in 20% extragonadal sites being affected. The most common extragonadal manifestations are the rectosigmoid and the re…

Die Differenzialdiagnose der Endometriose ist schwierig, es gibt keine pathognomonischen Symptome, ihre Ursachen sind unbekannt, ihr Fortschreiten ist variationsreich und nur unvollständig geklärt. Das Beschwerdebild hängt von der Lokalisat…

It was the aim of this paper to assess whether GnRH agonist and add-back therapy is an important post operative and long-term therapeutical supplement in the treatment of genital endometriosis, especially in cases of chronic pain. Although …

UNLABELLED: Patients with severe endometriosis involving the rectovaginal septum and bowel makes surgery necessary. The laparoscopic approach offers the possibility to perform the complete resection with minimal invasive techniques. Small l…

Numerous medical, surgical, and combined therapies have been proposed in the management of endometriosis. This range of treatment options contrasts remarkably with the evidence regarding their respective proven success rates. An exact preop…

Endometriosis is a varied and unspecific disorder, which can be detected by way of subtle diagnostics in almost every woman. In one case it is a minor accidental finding, in another case it is a cancer-like, mostly incurable, chronic painfu…

Progestins are used for the treatment of endometriosis and endometriosis related complains in low dosages since more than four decades. Progestins induce incomplete regression of endometriotic implants only, they have a high recurrence rate…

Endometriosis affects a 10 % of women during their reproductive years. Unequoral statistics concerning the incidence of adenomyosis are not available although a combined occurrence of both diseases is found in a 20 % of cases. The risk that…

Die Endometriose gehört zu den häufigsten gutartigen gynäkologischen Erkrankungen. Schätzungen gehen davon aus, dass 10 % bis 50 % der Frauen im reproduktionsfähigen Alter eine Endometriose haben [1] [2]. In selektionierten Kollektiven, wie…

OBJECTIVE: As a clinically significant syndrome in the field of gynaecology, chronic pelvic pain syndrome (CPPS) leads to illnesses which are prolonged over many years and, in some cases, to a high incidence of surgical intervention. Answer…

The authors described a rare case of spontaneous splenic rupture following abdominal hysterectomy in a patient with adenomyosis, severe sideropenic anemia and initiated anticoagulant therapy with low molecular heparin.

Endometriosis is a benign, chronic disease with high incidence during the female fertile period. Conservative treatment is dominated by the use of GnRH-analog substances, Gestagens and Danazol. As a case report we present the signs and symp…

A report is given about 486 patients, who were operated because of suspicion of adhesion in 74 cases (15.2%), of an adnexal tumor 116 (23.9%), endometriosis 9 (1.9%), infertility 24 (4.9%), irreversible contraception 42 (8.6%) or chronic ab…

Leptin is mainly synthesized by adipocytes and might represent the connecting link between fatty tissue and brain. In reference to reproduction, leptin resistance could play a role particularly in the pathogenesis of the PCO syndrome. Howev…

Endometriosis and infertility are frequently associated. There is controversy in the literature about the causal correlation. There is no doubt, that progressed disease causes infertility by mechanical disturbances of the reproductive organ…

Endometriosis is a proliferative disease, which is often diagnosed with delay. Laparoscopy and histology are necessary for diagnosis. Different factors influence the success of therapy. Proliferative markers are very important for the diffe…

Few cases of surgical scar endometriosis have been reported yet, which may occur following episiotomies and caesarean sections. The classic presentation is that of a tender mass becoming symptomatic with menstruation. Patients are complaini…

The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…

In a study 112 patients with histologically confirmed mostly recurrent endometriosis underwent a "three-step" therapy. Surgical removal of endometriosis implants was followed by a 6-months treatment with 3.75 mg of leuprorelin acetate depot…

OBJECTIVE: Endometriosis is one of the most common benign gynaecological diseases. Its aetiology is uncertain and there are many unanswered questions about its pathogenesis and treatment. MATERIAL AND METHODS: Medline search of relevant pub…

319 Patients are retrospectively competed, which underwent an inpatient or outpatient gynecological laparoscopy in 1992. Equality exists for martial status, education degree, nationality, anesthesiological risk and social structure. Outpati…

After bioptical diagnosis of endometriosis, 81 patients were treated with GnRH-agonists buserelin or leuprolide for six months. Biopsies before and after treatment were used to test a semiquantitative score-system, regarding atrophy of glan…

Beside of other cytokines and growth-factors Tumor Necrosis Factor Alpha (TNF-alpha) exerts as a macrophage-derived cytotoxic product a variety of immunologic effects in the human organism. It is also an important angiogenetic factor and re…