Sijun Yang

No ORCID on file · 11 papers in corpus · active 2002-2010

Study types

  • article 5
  • review 3
  • book-chapter 2
  • other 1

Condition tags

  • endometriosis 10
  • infertility 1
book-chapter 2010
The Biology of Endometriosis
·doi:10.4324/9780203319390_chapter_9
review 2004
Aromatase and endometriosis
Seminars in reproductive medicine ·doi:10.1055/s-2004-823026

Aromatase p450 (p450arom) is the key enzyme for biosynthesis of estrogen, which is an essential hormone for the establishment and growth of endometriosis. There is no detectable aromatase enzyme activity in normal endometrium; therefore, es…

article 2004
Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.01.048

ObjectiveTo determine the role of P and its nuclear receptor PR in the growth of ectopic uterine tissue of mice with or without a disrupted PR gene.DesignAnimal study.SettingAcademic medical center.Animal(s)Female wild-type (WT) and transge…

book-chapter 2003
Treatment with Aromatase Inhibitors
·doi:10.1201/b14235-12
review 2002
Estrogen Production and Metabolism in Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02767.x

Aromatase activity is absent in normal endometrium. In contrast, aromatase is expressed aberrantly in endometriosis, which gives rise to strikingly high levels of aromatase activity in this tissue. Both aromatase expression and activity are…

article 2002
Genetic or Enzymatic Disruption of Aromatase Inhibits the Growth of Ectopic Uterine Tissue
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.7.8683

Aromatase P450 (P450arom) is the key enzyme for the biosynthesis of estrogen that is essential for the growth of human endometriosis, a pathology characterized by endometrium-like tissue on the peritoneal surfaces of abdominal organs manife…

article 2002
Intact progesterone receptors are essential to counteract the proliferative effect of estrogen in a transgenic mouse model of endometriosis
·doi:10.1016/s0015-0282(02)03606-3
review 2002
Mechanisms of excessive estrogen formation in endometriosis
Journal of reproductive immunology ·doi:10.1016/s0165-0378(01)00132-2

Estrogen is produced in a number of human tissues including the ovary, placenta and extraglandular sites such as adipose tissue, skin and the brain. Aromatase is the key enzyme that regulates estrogen formation in these tissues. Aromatase a…

article 2002
Regulation of Aromatase P450 Expression in Endometriotic and Endometrial Stromal Cells by CCAAT/Enhancer Binding Proteins (C/EBPs): Decreased C/EBPβ in Endometriosis Is Associated with Overexpression of Aromatase
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.5.8486

In human endometriotic stromal cells, markedly high levels of aromatase P450 (P450arom) mRNA and promoter II activity are present and can be vigorously stimulated by PGE(2) via a cAMP-dependent pathway to give rise to physiologically signif…

article 2002
Wilms’ tumor 1 inhibits aromatase P450 expression in human cells and is downregulated in endometriosis vs. endometrium-derived stromal cells
·doi:10.1016/s0015-0282(02)03385-x
other 2002
WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2002-020522

The orphan nuclear receptor steroidogenic factor-1 (SF-1) induces the expression of Müllerian inhibiting substance (MIS) and many steroidogenic genes, including aromatase P450 (P450arom). Dosage-sensitive sex reversal adrenal hypoplasia con…