Mitsutoshi Tamura

No ORCID on file · 15 papers in corpus · active 1996-2010

Study types

  • article 7
  • review 5
  • book-chapter 2
  • other 1

Condition tags

  • endometriosis 12
  • mesh:D004715 10
  • dysmenorrhea 1
  • infertility 1
book-chapter 2010
The Biology of Endometriosis
·doi:10.4324/9780203319390_chapter_9
article 2006
A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.01.057
review 2005
Aromatase in endometriosis and uterine leiomyomata
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2005.04.012
review 2005
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment
Pharmacological reviews ·doi:10.1124/pr.57.3.6

A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition of which effectively eliminates estrogen production. Aromatase inhibitors successfully treat breast cancer and endometriosis, whereas their roles in…

review 2004
Aromatase and endometriosis
Seminars in reproductive medicine ·doi:10.1055/s-2004-823026

Aromatase p450 (p450arom) is the key enzyme for biosynthesis of estrogen, which is an essential hormone for the establishment and growth of endometriosis. There is no detectable aromatase enzyme activity in normal endometrium; therefore, es…

article 2004
Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.01.048
book-chapter 2003
Treatment with Aromatase Inhibitors
·doi:10.1201/b14235-12
review 2002
Estrogen Production and Metabolism in Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02767.x

Aromatase activity is absent in normal endometrium. In contrast, aromatase is expressed aberrantly in endometriosis, which gives rise to strikingly high levels of aromatase activity in this tissue. Both aromatase expression and activity are…

article 2002
Genetic or Enzymatic Disruption of Aromatase Inhibits the Growth of Ectopic Uterine Tissue
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.7.8683

Aromatase P450 (P450arom) is the key enzyme for the biosynthesis of estrogen that is essential for the growth of human endometriosis, a pathology characterized by endometrium-like tissue on the peritoneal surfaces of abdominal organs manife…

article 2002
Intact progesterone receptors are essential to counteract the proliferative effect of estrogen in a transgenic mouse model of endometriosis
·doi:10.1016/s0015-0282(02)03606-3
review 2002
Mechanisms of excessive estrogen formation in endometriosis
Journal of reproductive immunology ·doi:10.1016/s0165-0378(01)00132-2
article 2002
Regulation of Aromatase P450 Expression in Endometriotic and Endometrial Stromal Cells by CCAAT/Enhancer Binding Proteins (C/EBPs): Decreased C/EBPβ in Endometriosis Is Associated with Overexpression of Aromatase
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.5.8486

In human endometriotic stromal cells, markedly high levels of aromatase P450 (P450arom) mRNA and promoter II activity are present and can be vigorously stimulated by PGE(2) via a cAMP-dependent pathway to give rise to physiologically signif…

article 2002
Wilms’ tumor 1 inhibits aromatase P450 expression in human cells and is downregulated in endometriosis vs. endometrium-derived stromal cells
·doi:10.1016/s0015-0282(02)03385-x
other 2002
WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2002-020522

The orphan nuclear receptor steroidogenic factor-1 (SF-1) induces the expression of Müllerian inhibiting substance (MIS) and many steroidogenic genes, including aromatase P450 (P450arom). Dosage-sensitive sex reversal adrenal hypoplasia con…

article 1996
Juvenile Adenomyotic Cyst of the Corpus Uteri with Dysmenorrhea.
The Tohoku journal of experimental medicine ·doi:10.1620/tjem.178.339

The clinical and pathological features of an apparently unique case of an endometrial cyst of the uterus are reported. The cyst was located within the myometrium of a 16-year-old woman suffering from dysmenorrhea. After excision of the cyst…