Grümmer R

No ORCID on file · 8 papers in corpus · active 2001-2014

Study types

  • article 4
  • review 3
  • other 1

Condition tags

  • endometriosis 8
  • infertility 2
other 2014
Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture
Journal of reproductive immunology ·doi:10.1016/j.jri.2014.08.004

Heterologous endometriosis mouse models characterized by transplantation of human endometrial tissue into immunodeficient mice are widely used to develop novel treatment strategies for this gynecological disease. The majority of these exper…

review 2013
Translational Animal Models to Study Endometriosis-Associated Infertility
Seminars in reproductive medicine ·doi:10.1055/s-0032-1333477

Although there is an apparent association between endometriosis and impaired fertility, the pathophysiology of the reduced fecundity in women with endometriosis still remains unclear. Reproduction is a complex and multifactorial process, an…

article 2009
Connexin expression pattern in the endometrium of baboons is influenced by hormonal changes and the presence of endometriotic lesions
Molecular human reproduction ·doi:10.1093/molehr/gap060

Experimentally induced endometriosis in baboons serves as an elegant model to discriminate between endometrial genes which are primarily associated with normal endometrial function and those that are changed by the presence of endometriotic…

article 2009
Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model
Molecular human reproduction ·doi:10.1093/molehr/gap063

Progestins are successfully used in the treatment of endometriosis; however, the exact mechanisms of their action are still unsolved. We here focused on the effect of different progestins on parameters of extracellular matrix degradation an…

article 2007
Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.11.153

ObjectiveTo investigate the regulation of estrogen-converting enzymes in human ectopic endometrial tissue.DesignAnimal study.SettingAcademic medical center.Animal(s)Sixty female nude mice with implanted human endometrial tissue.Patient(s)Tw…

review 2006
Animal models in endometriosis research
Human reproduction update ·doi:10.1093/humupd/dml026

Endometriosis is a common gynaecological disease, defined as the presence of endometrial tissue outside the uterus, causing pelvic pain and subfertility in approximately 10% of women of reproductive age. Current therapies lead to pain relie…

review 2005
Vascular development in endometriosis
Angiogenesis ·doi:10.1007/s10456-005-9005-x

Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professiona…

article 2001
Peritoneal endometriosis: validation of an in-vivo model
Human Reproduction ·doi:10.1093/humrep/16.8.1736

BACKGROUND: The current medical treatment of endometriosis, a common gynaecological disease, is still associated with a high recurrence rate. To establish an appropriate in-vivo model to evaluate new therapeutic strategies we validated the …