Olivier Donnez

No ORCID on file · 50 papers in corpus · active 1997-2025

Study types

  • article 29
  • review 10
  • other 7
  • letter 2
  • editorial 1

Condition tags

  • endometriosis 36
  • infertility 9
  • adenomyosis 9
  • dyspareunia 6
  • dysmenorrhea 5
  • chronic_pelvic_pain 4
  • endometrioma 3
  • bowel_endometriosis 2
other 2025
Fertility and sterility ·doi:10.1016/j.fertnstert.2025.03.007
rct 2024
Human Reproduction ·doi:10.1093/humrep/deae076

STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone ac…

review 2023
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2023.102398

Cesarean scar disorder (CSD) is an entity recently defined as uterine niche with at least one primary or 2 secondary symptoms. CSDs can be visualized by hysterosalpingography, transvaginal sonography, saline infusion sonohysterography, hyst…

letter 2023
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.07.012
article 2023
·doi:10.1016/j.aidsoi.2023.07.004
other 2022
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2021.09.019

RESEARCH QUESTION: Does a once-daily regimen of linzagolix, a new oral gonadotrophin-releasing hormone (GnRH) antagonist, given at a fully suppressive dose (200 mg) for 12 weeks, followed by a partially suppressive dose (100 mg) for a furth…

review 2021
Journal of clinical medicine ·doi:10.3390/jcm10215183

Deep endometriosis infiltrating the rectum remains a challenging situation to manage, and it is even more important when ureters and pelvic nerves are also infiltrated. Removal of deep rectovaginal endometriosis is mandatory in case of symp…

article 2021
·doi:10.1016/j.fertnstert.2021.07.881
letter 2021
Fertility and sterility ·doi:10.1016/j.fertnstert.2021.01.038
article 2021
·doi:10.1093/humrep/deab130.298

Abstract Study question Is a once daily regimen of the GnRH antagonist, linzagolix, high-dose (200mg) for 12 weeks then low-dose (100mg) for 12 weeks, effective in severe adenomyosis? Summary answer After 12 weeks, there was marked shrinkag…

article 2021
Journal of clinical medicine ·doi:10.3390/jcm10245794

(1) Background: The aim of the present pilot study was to study the effect of a new oral gonadotropin-releasing hormone antagonist on adenomyosis. (2) Methods: Eight premenopausal women, aged between 37 and 45 years, presenting with heavy m…

review 2020
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2020.05.006

Deep endometriosis (DE) is considered to be one of the most challenging conditions to manage, especially when it invades surrounding organs like the rectum. Surgical excision of deep rectovaginal endometriosis is required when lesions are s…

article 2020
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.04.017

ObjectiveTo compare the efficacy of a selective progesterone receptor modulator, ulipristal acetate, and a gonadotropin-releasing hormone antagonist, linzagolix, in a case of severe uterine adenomyosis.DesignCase report.SettingPrivate clini…

article 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.01.035

Like endometriosis, uterine adenomyosis is another enigmatic disease and remains a source of controversy. Uterine adenomyosis is characterized by the presence of endometrial glands in the myometrium. Two main theories may explain its pathog…

article 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.08.016

ObjectiveTo study the mechanisms of invasion and innervation of deep endometriosis in women.DesignMorphologic and immunohistochemical analysis of human endometriotic lesions.SettingAcademic research unit.Patient(s)Seventeen biopsy samples o…

editorial 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.10.003
review 2018
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.12.030

Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and severity of symptoms, its pathogenesis and etiology have not yet b…

article 2018
·doi:10.1016/s0015-0282(18)30247-4
review 2017
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.09.006

Deep endometriosis (DE) remains the most difficult endometriotic entity to treat. Medical treatment for DE can reduce symptoms but does not cure the disease, and surgical removal of the lesion is required when lesions are symptomatic, impai…

other 2017
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.09.033

OBJECTIVE: To evaluate gynecological and obstetrical outcomes, as well as remaining myometrial thickness, after laparoscopic repair of a cesarean scar. DESIGN: Observational study and prospective evaluation of the remaining myometrium befo…

article 2017
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.01.005

ObjectiveTo evaluate deep nodular endometriotic lesions induced in baboons over 12 months and analyze collective cell migration and nerve fiber density.DesignMorphologic and immunohistochemical analysis of endometriotic lesions induced in b…

review 2016
Panminerva medica

Endometriosis remains a very enigmatic and perplexing disease. The exact mechanism by which endometriosis causes infertility is still unclear. In the present paper, we will review possible mechanisms leading to subfertility or infertility i…

review 2016
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.07.1075

Endometriosis is a disorder associated with a general inflammatory response in the peritoneal cavity. Oxidative stress is a potential factor involved in the pathophysiology of this disease, and reactive oxygen species (ROS) are implicated i…

article 2015
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.05.011

ObjectiveTo determine the implications of collective cell migration in the invasion phenomenon observed in deep endometriotic lesions induced in a baboon model.DesignStudy of morphology and collective cell migration markers in invasive and …

article 2014
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.12.049

ObjectiveTo evaluate the effects of endometriomas on the regulation of early follicular development.DesignHistologic analysis of prospectively collected biopsy samples.SettingResearch unit in a university hospital.Patient(s)Women <40 years …