Guzeloglu-Kayisli O

No ORCID on file · 12 papers in corpus · active 2004-2017

Study types

  • article 4
  • review 3
  • other 1

Condition tags

  • endometriosis 7
  • infertility 1
  • adenomyosis 1
review 2017
Endoplasmic Reticulum Stress and Homeostasis in Reproductive Physiology and Pathology
International journal of molecular sciences ·doi:10.3390/ijms18040792

The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts directly or indirectly with several cell organelles i.e., Golgi bodies, mitochondria and proteasomes. The ER is usually associated with large numbers of …

article 2017
p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719117725828

BackgroundLocal pro-inflammatory environment and enhanced cell survival contribute to the endometriosis development. A serine/threonine kinase p38 mitogen-activated protein kinase (MAPK) mediates intracellular signaling of cytokine producti…

article 2017
The extracellular signal‐regulated kinase 1/2 triggers angiogenesis in human ectopic endometrial implants by inducing angioblast differentiation and proliferation
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12760

PROBLEM: The role of extracellular signal-regulated kinase (ERK)1/2-mediated angiogenesis during endometriotic nidation is unknown. We posit that ERK1/2-induced angioblast differentiation and proliferation promotes ectopic endometrial angio…

review 2016
The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding
Human reproduction update ·doi:10.1093/humupd/dmw004

BACKGROUND: Human pregnancy requires robust hemostasis to prevent hemorrhage during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification of spiral arteries and post-partum processes. However, decidual hemorr…

2015
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells.
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.02.035

ObjectiveTo analyze the association of micro-ribonucleic acid (miRNA) expression with the number of oocytes retrieved, in women undergoing in vitro fertilization (IVF).DesignExperimental study.SettingAcademic medical center.Patient(s)A tota…

2014
Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH.
Molecular human reproduction ·doi:10.1093/molehr/gau024

Genes critical for fertility are highly conserved in mammals. Interspecies DNA sequence variation, resulting in amino acid substitutions and post-transcriptional modifications, including alternative splicing, are a result of evolution and s…

article 2014
mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2013-3488

BACKGROUND: Cytokines and growth factors play important roles in endometrial function and the pathogenesis of endometriosis. mRNAs encoding cytokines and growth factors undergo rapid turnover; primarily mediated by adenosine- and uridine-ri…

2013
Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary.
Endocrinology ·doi:10.1210/en.2013-1341

GnRH agonists (GnRHa) are increasingly used for fertility preservation in women undergoing gonadotoxic chemotherapy. However, the protective mechanisms of action for these compounds have not yet been elucidated. In this study, we aimed to d…

review 2009
Immune-endocrine interactions in endometriosis
Frontiers in bioscience (Elite edition) ·doi:10.2741/E39

Endocrine and immune systems are among the most essential regulators of endometrial physiology, and immune-endocrine interactions are likely to be involved in the pathogenesis of endometriosis. Endometriosis is an inflammatory, estrogen-dep…

2009
The role of growth factors and cytokines during implantation: endocrine and paracrine interactions.
Seminars in reproductive medicine ·doi:10.1055/s-0028-1108011

Implantation, a critical step for establishing pregnancy, requires molecular and cellular events resulting in uterine growth and differentiation, blastocyst adhesion, invasion, and placental formation. Successful implantation requires a rec…

other 2008
DNA-binding ability of NF-kappaB is affected differently by ERalpha and ERbeta and its activation results in inhibition of estrogen responsiveness
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719108317583

Estrogenic effects involve interactions between estrogen receptors (ERs), response elements, and nuclear proteins. It is hypothesized that interaction between ER and NF-kappa B may affect the regulation of responsive genes. Electrophoretic …

article 2004
Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8
Fertility and Sterility ·doi:10.1016/j.fertnstert.2003.11.015

ObjectiveTo evaluate the effect of interleukin-8 (IL-8) on endometrial stromal cell metalloproteinase (MMP) activity and invasiveness.DesignExperimental laboratory study.SettingUniversity medical center.Patient(s)Reproductive age women with…