Wang R

Polycystic ovary syndrome (PCOS) is a common endocrine disorder with a complex pathogenesis that includes disordered follicle development, hypothalamic-pituitary-ovarian (HPO) axis dysfunction, hyperandrogenemia, and insulin resistance. The…

Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association meta-analysis of generalized anxiety symptom severity in 693,869 individua…

The immune system is a pivotal regulator of reproductive physiology, maintaining tissue homeostasis essential for successful pregnancy while contributing to infertility and reproductive disorders when dysregulated. Natural products represen…

OBJECTIVE: To investigate whether the clinical predictors of achieving a clinical pregnancy differ between fresh and frozen embryo transfer cycles in patients with recurrent implantation failure (RIF) undergoing their first ART treatment af…

Obesity is a systemic metabolic disorder that is inducing factor for other diseases such as diabetes mellitus, cardiovascular diseases, malignancies, hepatic dysfunction, renal dysfunction and endometrial diseases. Emerging evidence has sho…

Fisetin, a flavonoid widely present in natural plants, exhibits diverse pharmacological activities including antioxidant, anti-inflammatory, anti-apoptotic, and anti-aging effects. Its protective roles within the mammalian reproductive syst…

IntroductionTamoxifen is a cornerstone of endocrine therapy for estrogen receptor-positive breast cancer; however, its partial estrogen agonist activity in the endometrium predisposes patients to hyperplasia and, in some cases, malignant tr…

BACKGROUND: Adenomyosis occurs when tissue from the inner lining of the endometrium grows into the muscle wall of the myometrium. Previous studies have suggested that High-Intensity Focused Ultrasound (HIFU) combined with medications may im…

BackgroundUnexplained recurrent spontaneous abortion (URSA) poses a significant clinical challenge with an elusive pathogenesis. FABP4 is crucial for lipid homeostasis and placental development, but its specific role and regulatory mechanis…

BackgroundChronic endometritis (CE), a persistent inflammatory condition of the endometrial lining, is clinically linked with adverse reproductive outcomes. It is currently hypothesized to be associated with infection, and is often treated …

ObjectiveTo evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation.DesignMulticentre, double blind, placebo controlled, randomised clinical trial.Settin…

BackgroundDysmenorrhea is a cramping pain during menstrual period and the leading cause for recurrent short-term school absenteeism among adolescent girls. However, evidence on the factors associated with the occurrence of dysmenorrhea, sch…

Endometrial immune disorders create an inhospitable endometrial environment for embryonic nidation in endometriosis. CD8 + tissue resident memory T cells (CD8 +TRM) are abundant tissue resident immune cells in endometrium, but the effect of…

Endometriosis is caused by the migration of endometrial cells to locations outside the uterine lining. Despite the increasing prevalence of endometriosis, there has been limited research on genetic effects, and its molecular mechanisms rema…

The incidence of urothelial carcinoma (UC) ranks second among all urological cancers, accounting for over 90% of malignant tumors in bladder. Patients diagnosed with UC experience a lower quality of life due to rapid progression of the dise…

Curcumol (Cur) has been found to be useful in improving Endometriosis (EMS), however its mechanism of action is still not completely understood. Based on this, the current study was carried out to investigate the mechanism of Cur on the inv…

Drug repositioning presents a compelling strategy to accelerate therapeutic development by uncovering new indications for existing compounds. However, current computational methods are often limited in their ability to integrate heterogeneo…

BackgroundDiabetes mellitus (DM) is one of the most common endocrine disorders affecting various physiological systems and tissues, including the reproductive organs in men. However, the consequences of DM for male individuals undergoing as…

OBJECTIVE: Zishen Quyu Jiedu formula (ZQYJDF) is a commonly used prescription for endometriosis (EMs) with clinical efficacy. However, its active components and potential mechanisms remain unknown. This study aimed to identify the key targe…

Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication in reproductive medicine, demonstrating considerable potential for both understanding and treating reproductive disorders. By precisely regulating…

We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of wh…

The increased risk of infertility and endometrial lesions (such as endometrial hyperplasia or cancer) in polycystic ovary syndrome (PCOS) are closely associated with the lack of cyclical transformation in the endometrium. However, the under…

ObjectiveTo study the correlation between anti-Müllerian hormone levels and pregnancy outcomes after in vitro fertilization/intracytoplasmic sperm injection in women with polycystic ovary syndrome, which remains controversial.MethodsThis re…