Chen P

Infertility is a prevalent clinical issue which disrupts normal human life and exerts an impact on fertility rates within the population. The increase in environmental pollutants, including acetyl tributyl citrate (ATBC), has given rise to …

OBJECTIVES: Accessory cavitated uterine malformation (ACUM) is a congenital Müllerian duct developmental anomaly. Clinically, it is commonly observed in young women presenting with progressive lower abdominal pain. Due to the small size of …

BACKGROUND: The clinical association between female reproductive disorders, such as endometriosis, polycystic ovary syndrome(PCOS), uterine leiomyoma, and female infertility and psychiatric disorders, such as major depressive disorder(MDD),…

PurposeTo investigate the hypothesis that an imbalance between the epithelial adhesion molecule E-cadherin and matrix metalloproteinases (MMPs) underlies the vaginal atrophy associated with menopause.MethodsThis cross-sectional study includ…

BackgroundRecurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) are major causes of pathological early pregnancy, yet their mechanisms remain poorly understood. This study aimed to identify shared molecular mediators and t…

Adenomyosis is a common gynecological disorder with incompletely understood pathogenesis. Through single-cell RNA sequencing of adenomyosis tissues, we identified epithelial-endothelial transition (EET) as a key pathological mechanism and d…

BackgroundCopy number variations (CNVs) of uncertain significance (VUS) are increasingly identified through prenatal and postnatal genetic testing, yet their clinical interpretation remains challenging. We report a neonate with hematologic …

Combined pulmonary fibrosis and emphysema (CPFE) and lung cancer cast intertwined shadows, yet the molecular nexus binding them remains largely obscured. By integrating high-resolution transcriptomic landscapes, extensive genome-wide associ…

Lili Zheng,1,* Huifang Lei,1,* Xiaoyi Tang,2 Yuanyin Zheng,3 Qiuzhen Wu,3 Peixuan Chen,1 Yanhong Chen,1 Liangzhi Cai4,5 1Department of Gynecology, Mindong Hospital Affiliated to Fujian Medical University, Ningde, People’s Republic of China;…

BackgroundThe main objective of this study was to summarize and analyze the pregnancy outcomes in the assisted reproductive technology (ART) population with subchorionic hematoma (SCH) in the first trimester. Moreover, we aimed to explore t…

The incidence of urothelial carcinoma (UC) ranks second among all urological cancers, accounting for over 90% of malignant tumors in bladder. Patients diagnosed with UC experience a lower quality of life due to rapid progression of the dise…

BackgroundCervical intraepithelial neoplasia grade 2 (CIN2) is one of the precursor stages before cervical lesions develop into cervical cancer. The spontaneous development of CIN2 is ambiguous. One part of CIN2 lesions will progress to cer…

BackgroundInfertility affects 8-12% of couples globally, manifesting as a complex reproductive disorder with varied causes, negatively impacting emotional, physical, and social well-being. Inflammation is implicated in many diseases, includ…

IntroductionRecurrent spontaneous abortion (RSA) demonstrates a complex pathogenesis. The uterine artery (UtA) Doppler ultrasound monitoring is clinically valuable for predicting RSA risk.ObjectiveThis study aimed to assess the type of bloo…

ObjectiveTo investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) tail anchoring to the superficial myometrium under hysteroscopic direct vision.MethodsFrom March 1, 2017, to March 1, 2022, 206 patients…

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, inc…

BackgroundLimited clinical research has focused on women with chronic kidney disease (CKD) undergoing assisted reproductive technology (ART). We aim to investigate the kidney outcome and the adverse pregnancy-related outcomes of CKD women a…

Background and aimsEnvironmental pollutants, particularly organochlorine insecticides like endosulfan (ENDO), are increasingly linked to liver toxicity and related diseases. Despite its widespread historical use, the mechanisms underlying E…

AIM: To explore whether preoperative vaginal dysbiosis influences the recurrence of endometrial polyps after hysteroscopic polypectomy. DESIGN: Retrospective-prospective observational cohort study. METHODS: A total of 679 patients from ou…

OBJECTIVE: This retrospective study investigated the prognostic significance and risk factors of benign pathologic types of background endometrium surrounding endometrial polyps (EPs). METHODS: We assessed 206 patients who underwent hyster…

BackgroundWith the increasing incidence of obesity and the childbearing-age delay among women, a debate over obesity's impacts on pregnancy and neonatal outcomes becomes hot. The potential negative effects of obesity and aging on fertility …

ObjectiveVery few and conflicting data are available regarding the correlation between circulating carbohydrate antigen 19-9 (CA19-9) levels and diabetic kidney disease (DKD) and its components including albuminuria and a low estimated glom…

BackgroundAbnormal endometrial blood flow causes a decrease in endometrial receptivity and is considered a relatively independent risk factor for recurrent implantation failure (RIF). This study aimed to explore the potentially functional c…

INTRODUCTION: Endometriosis (EM) is a widely recognized disorder in gynecological endocrinology. Although hormonal therapies are frequently employed for EM, their side effects and outcome limitations underscore the need to explore the genet…

Osteosarcoma is an aggressive form of bone cancer and affects the health in children and adolescents. Although conventional treatment improves the osteosarcoma survival, some patients have metastasis and drug resistance, leading to a worse …