Yang Y

Abstract Objective To analyze the clinical characteristics of hospitalized patients with benign gallbladder diseases based on a large dataset, and compare these findings with those from the physical examination population in existing liter…

STUDY QUESTION: What are the unrecognized risk factors for recurrent implantation failure (RIF) as defined in the ESHRE recommendation? SUMMARY ANSWER: Anti-Müllerian hormone (AMH) is the strongest predictor for RIF, followed by chronic en…

BACKGROUND: Polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) are two prevalent and interrelated disorders that pose an increasingly significant global health burden. Cellular senescence may represent a pivotal process dr…

Abstract The characteristic of endometriosis is that the endometrial tissue grows in non-endometrial parts such as the pelvis and ovaries, leading to infertility and chronic pain. However, its pathophysiology is still unclear. Using high-p…

BACKGROUND: The sirtuin family is well recognized for its crucial involvement in various cellular processes. Nevertheless, studies on its role in the human endometrium are limited. This study aimed to explore the expression and localization…

PURPOSE: This study aimed to explore the roles of spermatozoal sialidase NEU1 and NEU3 in affecting the fertilization rate of in vitro fertilization (IVF), and whether sperm sialidase NEU1 and NEU3 can be used as predictors of IVF outcome. …

Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes…

Diminished ovarian reserve (DOR) is characterized by a decrease in the quantity and quality of oocytes, leading to reduced chances of natural conception and a poorer response to fertility treatments. Along with these reproductive challenges…

This study aims to investigate the association between multidimensional frailty phenotypes and recurrent pregnancy loss (RPL) in reproductive-aged women. This cross-sectional study analyzed data from 6,438 reproductive-aged women participat…

BACKGROUND: Shear wave elastography (SWE) can be used to detect the stiffness of the myometrium and lesion of the uterus, shear wave dispersion (SWD) can be used to detect the viscoelasticity, and magnetic resonance imaging (MRI) can be use…

Ovulatory dysfunction (OD) is one of the main causes of infertility in women of childbearing age, which not only affects their reproductive ability, but also physical and mental health. Traditional treatment strategies have limited efficaci…

BACKGROUND: Endometriosis (EMS) is associated with a markedly increased incidence of depression and anxiety, primarily due to cyclic pain, concerns about infertility from impaired ovarian function, and fear of disease recurrence. Surgery an…

OBJECTIVE: To investigate the impact of changes in luteinizing hormone (LH) levels during ovulation induction using flexible gonadotropin-releasing hormone antagonist (GnRH-A) regimens in POSEIDON groups 1 and 2 on the clinical outcomes of …

Endometriosis has been linked to several systemic complications, including cardiovascular disease (CVD), atrial fibrillation (AF), heart failure (HF), hypertension, stroke, and ischemic stroke. The potential causal relationship between endo…

Endometriosis-associated ovarian carcinoma (EAOC) predominantly arises from the malignant transformation of endometriomas, yet the mechanism is incompletely defined. Spatial transcriptomic analysis of human specimens of normal endometrium, …

BACKGROUND: Diet, lifestyle, and oxidative stress have been linked to female infertility, with the Oxidative Balance Score (OBS) serving as a comprehensive indicator of an individual's oxidative and antioxidant status. This study aims to in…

Abstract Background Patients with adenomyosis are thought to exist in a hypercoagulable state; however, the specific alterations in thromboelastography (TEG) remain to be elucidated. This study aimed to assess changes in TEG metrics and t…

A considerable number of women of reproductive age suffer from endometriosis worldwide. There is a significant physical, mental, and financial burden on patients affected by this condition in terms of pelvic pain, either continuously or int…

Sterile and infection-associated inflammatory diseases are becoming increasingly prevalent worldwide. Conventional drug therapies often entail significant drawbacks, such as the risk of drug overdose, the development of drug resistance in p…

Endometrial cancer arising in adenomyosis (EC-AIA), i.e., malignant transformation of the endometrium within adenomyotic foci, is a very unusual condition. We report a postmenopausal woman who had an unexpected diagnosis of uterine serous c…

Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maint…

The paper introduces Professor ZHAO Hong's clinical experience and the thinking of diagnosis and treatment for gynecological diseases based on spleen-stomach theories of TCM and explore the effects of the dysfunction of spleen and stomach o…

BACKGROUND: Caffeine has been suggested to have a relationship with endometriosis as a widely consumed psychoactive substance, although findings are inconsistent. OBJECTIVE: This study explored the potential associations and threshold effe…

PurposeThis study aimed to develop a predictive model for assessing clinical pregnancy probabilities in patients undergoing frozen-thawed cycles with single Day 6 blastocyst transfers.MethodsWe conducted a two-center retrospective cohort st…