Luo Y

Endometriosis (EMS) is a chronic disease characterized by unclear etiology, influenced by various genetic and environmental factors, with no definitive biomarkers available for early screening. Recent studies suggest that the abdominal micr…

BackgroundPelvic organ prolapse (POP) significantly impacts women's quality of life, with laparoscopic sacrocolpopexy (LSC) considered the gold standard for treatment. However, LSC carries risks of complications, prompting exploration of al…

Endometriosis is a chronic painful condition affecting 10% of reproductive-aged women with a high prevalence of overlapping gastrointestinal symptoms. There is a significant diagnostic delay for endometriosis and current screening practices…

Abnormal development of granulosa cells is widely recognized as a critical factor contributing to polycystic ovary syndrome (PCOS). However, the precise etiology and underlying mechanisms of this disorder remain largely elusive. Accumulatin…

Mucinous cystic neoplasm of the liver (MCN-L) is a rare benign tumor accounting for less than 5% of all liver cysts, with MCN-L in the hilar region being exceptionally uncommon and often misdiagnosed due to its complex presentation. A 48-ye…

Oxidative stress plays a central role in reproductive disorders, with food bioactive compounds offering therapeutic potential through their antioxidant properties. This review examines antioxidant active ingredients from plant-based foods a…

Previous research has indicated that Polyphyllin I (PPI) possesses potent anticancer properties. However, its impact on endometriosis remains unexplored. This study aims to investigate the inhibitory effects of PPI on ectopic endometrial st…

BackgroundInformation on the impact of Progestin-primed ovarian stimulation (PPOS) protocol on embryo euploid status and preimplantation genetic testing for aneuploidy (PGT-A) outcomes is limited compared with other ovarian stimulation prot…

Malic enzyme 1 (ME1) plays a key role in promoting malignant phenotypes in various types of cancer. ME1 promotes epithelial-mesenchymal transition (EMT) and enhances stemness via glutaminolysis, energy metabolism reprogramming from oxidativ…

BACKGROUND: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue outside the uterine cavity, often leading to pain, infertility, and psychological distress. Effective perioperative care is c…

BackgroundDysmenorrhea, a common concern among female college students, is closely linked to anxiety and depression, particularly during the early menstrual phase (the first one to two days of menstruation), when cramping pain in the lower …

BackgroundAlcohol use is a major risk factor for pancreatitis and global mortality. Despite its impact, comprehensive analyses of the burden across regions and sociodemographic strata remain scarce. This study examines global trends (1990-2…

This review examines the neurobiological mechanisms by which plant-derived compounds influence women's reproductive health through the neuroendocrine-reproductive axis. Gynecological disorders frequently present with neurological manifestat…

ObjectiveThe potential association between rheumatoid arthritis (RA) and cervical cancer risk is still debated and necessitates additional clinical investigations. This study aimed to explore this relationship using Mendelian randomization …

BACKGROUND: The levonorgestrel-releasing intrauterine system (LNG-IUS) is now widely used for the treatment of heavy menstrual bleeding and endometrial hyperplasia, and its clinical application has been extended to adenomyosis. By releasing…

QiuXia Hu,1,* Yi Yao,2,* XiaoHui Xie,1 XiaoMei Zhong,1 Yong Luo,1 Xiaoqin Huang1 1Department of Gynecology, The First People’s Hospital of Neijiang, Sichuan, 641000, People’s Republic of China; 2Department of Cardiothoracic Surgery,…

ObjectiveThe aim of this study was to enhance the precision of categorization of endometrial lesions in ultrasound images via a data enhancement framework based on deep learning (DL), through addressing diagnostic accuracy challenges, contr…

BACKGROUND: Observational studies have found a correlation between the levels of blood lipids and the development and progression of endometriosis (EM). However, the causality and direction of this correlation is unclear. This study aimed t…

Endometriosis is a complex and heterogeneous condition affecting 10% of reproductive-age women, and yet, it often goes undiagnosed for several years. Limited observed heritability (7%) of large genetic association studies may be attributabl…

BACKGROUND: Endometriosis affects 10% of reproductive-age women, and yet, it goes undiagnosed for 3.6 years on average after symptoms onset. Despite large GWAS meta-analyses (N > 750,000), only a few dozen causal loci have been identified. …

BackgroundChronic salpingitis is one of the most common causes of female infertility. Luteal support is a critical step for embryo transfer. Here, we evaluated the effects of two luteal support regimens, intramuscular progesterone (IMP) and…

We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis consisting of a large portion (31%) of non-European samples across 14 biobanks worldwide as part of the Global Biobank Meta-Analysis Initiative …

Despite advancements in assisted reproductive technology, recurrent implantation failure (RIF) remains a challenge. Endometrial factors, including ferroptosis and immunity, may contribute to this issue. This study integrated bioinformatics …

Given the high concentration of iron in the micro-environment of ovarian endometriosis, it is plausible to hypothesize that ectopic endometrial cells may be more susceptible to undergoing ferroptosis. Manipulation of ferroptosis has been ex…