Xia Y

ObjectiveThe study aims to elucidate the factors associated with the short-term efficacy of ovarian vein embolization (OVE) in the treatment of pelvic venous insufficiency (PVI), to construct a predictive model for short-term efficacy of OV…

BACKGROUND: Ultrasound-based deep learning (DL) models for the precise diagnosis of endometrial cancer are insufficient. Our aim is to develop and validate an automatic multi-modal ultrasound DL prediction model for the accurate identificat…

RESEARCH QUESTION: Does peritoneal iron overload drive fibrosis in endometriosis through Nrf2 pathway dysfunction and the resulting ferroptosis, and can electroacupuncture intervene in this process? DESIGN: An endometriosis mouse model was…

BackgroundOvarian mucinous tumors are histologically classified into benign, borderline, and malignant categories, with borderline tumors generally demonstrating an intermediate prognosis. However, ovarian borderline mucinous tumors with ma…

STUDY OBJECTIVE: To evaluate the predictive value of preoperative triple pelvic examination combined with transvaginal sonography (TVS) for posterior pelvic deep endometriosis (DE). DESIGN: A prospective randomized controlled clinical stud…

Circadian rhythms are ~24 h endogenous rhythms driven by both central and peripheral clocks, with their core mechanism being a transcription‑translation feedback loop mediated by master clock genes. The present review outlines the organizat…

The management of nasopharyngeal cancer (NPC) is rapidly evolving, with immune checkpoint inhibitors emerging as a prominent treatment approach. However, drug development targeting specific molecular and cellular abnormalities in NPC has sl…

ObjectiveTo explore the role of endometrial defects in the pathogenesis of abnormal uterine bleeding (AUB).DesignRetrospective case-control study.SettingTwo tertiary centres.Population or sampleWe included 155 patients with caesarean scar d…

BackgroundAt present, laparoscopic cholecystectomy (LC) is the primary treatment for gallstone. Although the application of LC has been widespread in developed countries, the cost-effectiveness of LC in high-altitude, low-resource regions r…

Abstract Background Endometriosis (EMs) often leads to ovarian dysfunction and infertility. Its mechanism is closely associated with oxidative stress and ferroptosis induced by pelvic iron overload. Electroacupuncture (EA) has potential i…

Pancreatitis, an inflammatory disorder of the pancreas, remains a significant clinical challenge owing to its complex pathogenesis and the lack of reliable biomarkers for early diagnosis and effective treatment. Exosomes, small extracellula…

OBJECTIVE: Endometriosis increases ovarian cancer (OC) risk through genetic mutations, chronic inflammation, and hormonal dysregulation, yet the underlying molecular pathways remain underexplored. This study aims to identify endometriosis-a…

IntroductionThis study aimed to elucidate the molecular mechanisms underlying cervical precancerous lesions by employing bioinformatic approaches to identify key genes and signaling pathways.MethodsA comprehensive strategy was adopted, begi…

Due to the influence of economic, social and many other factors, there are more and more reproductive problems. Originally introduced for managing male factor infertility, intracytoplasmic sperm injection had become the most commonly used f…

BackgroundPatients with Polycystic ovary syndrome (PCOS) experienced endocrine disorders that may present vascular function changes. This study aimed to classify and predict PCOS by radial pulse wave parameters using machine learning (ML) m…

OBJECTIVE: To investigate the mechanism of Neferine in treating endometriosis fibrosis by TGF-β/ERK signaling pathway through a combination of network pharmacological analysis of Lotus embryos, in vivo animal experiments, and in vitro cell …

BackgroundFollicular microenvironment has been proposed as an important factor for oocyte grown and maturation. We sought to evaluate the oxidative stress and inflammatory levels in follicular fluid (FF) and association with embryo quality …

ObjectivesTo analyze the correlation between age and sperm DNA fragmentation index (DFI), and determine whether the number of eggs retrieved from the female partner was associated with the impact of sperm DFI on clinical pregnancy rates.Met…

OBJECTIVE: To explore the mechanism of Thunberg Fritillaria in treating endometriosis (EMs) based on network pharmacology and the effect of Peiminine on the MEK/ERK pathway. METHODS: We applied Chinese medicine system pharmacology analysis…

BackgroundIt has been consistently shown in several meta-analyses that infants born after ART have an excess of birth defects compared with those after spontaneous conception, however, the prevalence of birth defects among ART offspring in …

Emerging evidence suggests that children conceived through assisted reproductive technology (ART) have a higher risk of congenital heart defects (CHDs) even when there is no family history. De novo mutation (DNM) is a well-known cause of sp…

Although endometrioid carcinoma (EC) and endometrioid ovarian carcinoma (EnOC) display similar pathological features, their molecular characteristics remain to be determined. Somatic mutation data from 2777 EC, 423 EnOC, and 57 endometriosi…

BackgroundPsychological distress may exert a negative influence on reproductive function of couples at reproductive age. Couples seeking assisted reproductive technology (ART) treatment may have a higher prevalence of psychological distress…

There were few studies of cumulative live birth rates (CLBRs) based on multicenter reproductive clinical data from the general Chinese population. Here we report a retrospective cohort study, including 14 311 women with 17 315 cycles, in th…