Hayashi K

No ORCID on file · 23 papers in corpus · active 1967-2026

Study types

  • other 9
  • article 8
  • case-report 3

Condition tags

  • endometriosis 19
  • chronic_pelvic_pain 2
  • adenomyosis 2
  • dysmenorrhea 1
  • infertility 1
  • bladder_endometriosis 1
other 2026
bioRxiv : the preprint server for biology ·doi:10.64898/2026.02.06.704463

Endometriosis is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, non-hormonal therapies is urgently needed. We previously reported t…

other 2026
The Journal of clinical investigation ·doi:10.1172/JCI194136

This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an underlying m…

2025
Asian journal of endoscopic surgery ·doi:10.1111/ases.70197

IntroductionCesarean scar disorder (CSDi) is a pathological entity involving a myometrial defect at the site of a previous cesarean section, commonly associated with postmenstrual spotting, dysmenorrhea, and secondary infertility. While lap…

2025
Asian journal of endoscopic surgery ·doi:10.1111/ases.13412

IntroductionIn robot-assisted sacrocolpopexy (RSC) for patients with cystocele, accurate identification of the vaginal point Aa from the serosal side is crucial for surgical mesh placement in the appropriate position. We developed a novel P…

other 2025
Reproductive medicine and biology ·doi:10.1002/rmb2.12675

PURPOSE: This study evaluated the feasibility of single-nucleotide polymorphism (SNP) genotyping using dried blood spot (DBS) samples stored under various conditions, based on the genotyping success rate and concordance with whole blood res…

other 2025
bioRxiv : the preprint server for biology ·doi:10.1101/2025.01.23.634555

INTRODUCTION: Endometriosis is an inflammatory disease associated with chronic pelvic pain (CPP). Growing evidence indicates that endometriotic lesions are not the sole source of pain. Instead, central nervous system (CNS) dysfunction creat…

article 2024
Frontiers in endocrinology ·doi:10.3389/fendo.2024.1336496

Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation…

other 2024
Frontiers in immunology ·doi:10.3389/fimmu.2024.1396000

Endometriosis is a chronic inflammatory disease that causes debilitating pelvic pain in women. Macrophages are considered to be key players in promoting disease progression, as abundant macrophages are present in ectopic lesions and elevate…

other 2023
bioRxiv : the preprint server for biology ·doi:10.1101/2023.11.09.566474

Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation…

case-report 2022
Gan to kagaku ryoho. Cancer & chemotherapy

A 61-year-old woman was found to have calcifications in the CD region of the left breast. She had previously undergone total hysterectomy and bilateral oophorectomy for endometriosis at the age of 37 years. Since age 59 years, she had been …

article 2020
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.14209

AIM: To investigate the safety and efficacy of dienogest (DNG), a progestational 19-norsteroid, administered for 52 weeks in patients with primary and secondary dysmenorrhea. METHODS: A total of 147 patients with dysmenorrhea received 1 mg …

article 2020
The Tohoku journal of experimental medicine ·doi:10.1620/tjem.251.241

Endometriosis, a disease in which endometrial tissue proliferates outside the uterus, is a progressive disease that affects women in reproductive age. It causes abdominal pain and infertility that severely affects the quality of life in you…

other 2018
Cancer treatment and research communications ·doi:10.1016/j.ctarc.2017.11.002

OBJECTIVE: The aim of this study was to clarify the clinical, laboratory, and imaging findings of ovarian cancer in association with endometriotic cysts by detailed comparison of the findings of benign and malignant tumors. METHODS AND MAT…

2015
Surgical case reports ·doi:10.1186/s40792-015-0069-6

We report herein a 41-year-old female with a tubo-ovarian abscess (TOA), which microbial cultures showed to contain extended-spectrum beta-lactamase (ESBL)-producing E. coli, a causative agent of community-acquired infection. The patient in…

case-report 2014
Forensic science international ·doi:10.1016/j.forsciint.2014.04.032

Gynaecologic diseases unrelated to pregnancy are not generally associated with sudden death, which limits the number of case reports published in the field of forensic medicine. Presented in this paper is a fatal case in a middle aged woman…

case-report 2012
Hinyokika kiyo. Acta urologica Japonica

We report a case of vesical endometriosis that worsened during the early pregnancy period. A 37-year old woman had been under treatment for endometriosis (including vesical endometriosis) by a gynecologist during the past 10 years. She was …

article 2012
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/j.1447-0756.2012.02005.x

We present the case of a 37-year-old nulliparous woman in whom acute massive uterine bleeding during dienogest therapy was successfully treated using intrauterine balloon tamponade. Abnormal uterine bleeding and several cases of profuse ble…

other 2009
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.12.005

OBJECTIVE: To investigate menstrual cycle changes in expression by eutopic endometrium of a nonclassic human leukocyte antigen, HLA-G, which binds to the killer immunoglobulin-like receptor (KIR) 2DL4 (CD158d) on natural killer (NK) cells. …

article 2007
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.02.027

ObjectiveTo investigate the macrophage response in endometriosis by determining the expression and localization of human leukocyte antigen (HLA)-ABC and HLA-DR by the peritoneal fluid (PF) macrophages and PF concentrations of interferon (IF…

article 2006
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/j.1600-0897.2005.00332.x

PROBLEM: We investigated host immunologic responses to endometriosis by comparing immune cell surface antigens in peripheral blood (PB) and peritoneal fluid (PF) from women with endometriosis with those in PB and PF from other patients. MET…

article 2005
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.11.039

ObjectiveTo investigate the macrophage response in endometriosis, we determined expression of human leukocyte antigen (HLA)-ABC, HLA-DR, and their costimulatory molecules by peritoneal fluid (PF) macrophages.DesignCase-control study of immu…

other 1995
Nihon Sanka Fujinka Gakkai zasshi
article 1967
Geka chiryo. Surgical therapy

Cutaneous endometriosis is a well known but rare phenomenon. We present a case of spontaneous umbilical endometriosis. The patient revealed a polypoid, brown-blue nodule within the umbilical depression with the typical history of monthly bl…