Radosław Maksym

From an immunological perspective, infertility mechanisms encompass not only fertilization but also implantation, as well as both early and late pregnancy loss. Growing attention is being directed towards the influence of systemic disorders…

Abstract Background: Endometriosis is a common chronic gynaecological disorder related to the presence of ectopic foci of endometrial-like tissue mostly in the pelvic cavity. Pathogenesis of this disease may be associated with epithelia…

BACKGROUND: Endometriosis is a common chronic gynaecological disorder related to the presence of ectopic foci of endometrial-like tissue, mostly in the pelvic cavity. Pathogenesis of this disease may be associated with epithelial-to-mesench…

Endometriosis is a complex condition causing surgical challenges, sometimes leading to urogynecological complications, the diagnosis and treatment of which are not always obvious. We present a case of a 46-year-old woman with a history of s…

BACKGROUND: Endometriosis, due to its ambiguous symptoms, still remains one of the most difficult female diseases to treat, with an average diagnosis time of 7-9 years. The changing level of hypoxia plays an important role in a healthy endo…

Endometriosis is a common chronic disorder characterized by the growth of endometrium-like tissue outside the uterine cavity. The disease is associated with chronic inflammation and pelvic pain and may have an impact on the patient's fertil…

Infertility has been recognized as a civilizational disease. One of the most common causes of infertility is polycystic ovary syndrome (PCOS). Closely interrelated immunometabolic mechanisms underlie the development of this complex syndrome…

Premenstrual dysphoric disorder is a female affective disorder that is defined by mood symptoms. The condition is linked to unstable progesterone concentrations. Progestin supplementation is given in cases of threatened or recurrent miscarr…

Endometriosis is an inflammatory condition manifested by the presence of endometrial-like tissue outside of the uterine cavity. The most common clinical presentations of endometriosis are dysmenorrhea, infertility, and severe pelvic pain. F…

Endometriosis is one of the most common gynecological and systemic diseases, with a remarkable immune background. Patients suffer from pain and fertility reduction. Due to the distinct immune component, an immunotherapeutic approach may gai…

One of the leading health conditions associated with female infertility is endometriosis, which is the presence of endometrial-like tissue outside the uterine cavity. It is estimated that endometriosis can be demonstrated in up to half of i…

Endometriosis involvement of the urological tract may lead to significant disabilities. The involvement of the urological tract gives rise to severe complications that burden patient health and quality of life. Two cases of patients with se…

Endometrioza jest jednostką chorobową manifestującą się klinicznie jako złożony zespół objawów. Ze względu na różnorodny przebieg oraz zróżnicowane oczekiwania pacjentek wymaga kompleksowej i interdyscyplinarnej opieki medycznej. Stwierdzen…

Endometrioza jest przewlekłym zaburzeniem ginekologicznym, które dotyka 2-10% kobiet w wieku rozrodczym. Pomimo wielu lat badań patogeneza endometriozy nie jest do końca wyjaśniona, a z leczenie endometriozy wiąże się z licznymi kontrowersj…

Patogeneza endometriozy wynika z współdziałania czynników środowiskowych i genetycznych. Ze względu na częste występowanie oraz duży wpływ na życie i stan zdrowia, ustalenie ważnych czynników sprawczych endometriozy jest istotnym problemem …

Narastający problem niepłodności małżeńskiej wraz ze złożonym tłem patogenetycznym powoduje wiele kontrowersji dotyczących leczenia. Podstawą efektywnego leczenia jest właściwa diagnostyka i postępowanie. Nie bez znaczenia pozostaje efektyw…

Aberrant regulation of matrix metalloproteinases (MMPs) may be the primary cause of endometrial lesion formation in a group of predisposed women. Prospect for the genuine origin of endometriosis is ongoing, since retrograde menstruation lea…

STUDY QUESTION: Is endometriosis associated with changes in CD4⁺ CD25⁺ FOXP3⁺ regulatory T cells (Treg cells)? SUMMARY ANSWER: Endometriosis is associated with disturbed compartmentalization of CD25(high) FOXP3⁺ Treg cells. WHAT IS KNOWN …