Podłoże autoimmunologiczne rozwoju endometriozy.

Milena Skibińska, Radosław Maksym
In: Fides et Ratio, Vol 43, Iss 3 (2020) · 2020 · vol. 43(3) , pp. 373–378 · doi:10.34766/fetr.v43i3.315 · W3104448696
article OA: gold CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the autoimmune basis of endometriosis, noting increased incidence of autoimmune diseases and celiac disease in affected women, suggesting immunological dysregulation contributes to the condition's development and progression.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper reviews evidence that endometriosis, a chronic gynecological disorder, has familial aggregation and is associated with a higher incidence of autoimmune diseases and celiac disease, sometimes with mild symptoms or mainly genetic predisposition. It cites population-based and case-control studies and a systematic review/meta-analysis reporting co-occurrence or increased risk with conditions such as systemic lupus, Sjögren’s syndrome, rheumatoid arthritis, autoimmune thyroiditis, multiple sclerosis, Addison’s disease, and inflammatory bowel disease, and it discusses the hypothesis that immune dysregulation may create an “immune niche” enabling endometriosis lesion development. The authors explicitly state that there is no convincing data for a causal mechanism or common underlying cause linking these disorders. This paper is centrally about endometriosis — it focuses on the proposed autoimmune/immunological basis of endometriosis development and its comorbidity spectrum with autoimmune diseases.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometrioza jest przewlekłym zaburzeniem ginekologicznym, które dotyka 2-10% kobiet w wieku rozrodczym. Pomimo wielu lat badań patogeneza endometriozy nie jest do końca wyjaśniona, a z leczenie endometriozy wiąże się z licznymi kontrowersjami. Endometrioza występuje rodzinnie i asocjuje z innymi chorobami. W grupie pacjentek chorujących na endometriozę odnotowuje się znacznie podwyższoną zapadalność na choroby autoimmunologiczne oraz celiakię, często przebiegającą w sposób skąpoobjawowy lub stwierdza się jedynie genetyczną do niej skłonność. Udowodniono współwystępowanie, a czasem wielokrotnie zwiększone ryzyko zapadalności na endometriozę u pacjentek z toczniem układowym, zespołem Sjogrena, reumatoidalanym zapaleniem stawów, autoimmunologicznym zapaleniem tarczycy, stwardnieniem rozsianym, chorobą Addisona i nieswoistymi zapaleniami jelit. Chociaż nie ma przekonujących danych o możliwym mechanizmie przyczynowo- skutkowym łączącym te patologie z endometriozą lub o wspólnej przyczynie leżącej u podłoża tych zaburzeń to jednak postuluje się że dysregulacja immunologiczna ma związek z wytwarzaniem się niszy immunologicznej pozwalającej na powstawanie i progresję zmian typowych dla endometriozy. Diagnozując i lecząc pacjentki z endometriozą nie należy zapominać o spektrum chorób towarzyszących, spośród których część jest ciężkimi schorzeniami prowadzącymi do licznych powikłań.
Full text 3,764 characters · extracted from oa-html · 2 sections · click to expand

Abstract

Endometriosis is a chronic gynecological disorder that affects 2-10% of women of childbearing age. Despite many years of research, the pathogenesis of endometriosis is not fully understood, and the treatment of endometriosis is associated with numerous controversies. Endometriosis runs in families and is associated with other diseases. In the group of patients suffering from endometriosis, there is a significantly increased incidence of autoimmune diseases and celiac disease, which is often only mildly symptomatic or only genetically prone to it. The coexistence and sometimes multiple increased risk of endometriosis has been proven in patients with systemic lupus, Sjogren's syndrome, rheumatoid arthritis, autoimmune thyroiditis, multiple sclerosis, Addison's disease, and inflammatory bowel disease. Although there is no convincing data on a possible causal mechanism linking these pathologies with endometriosis or on a common cause underlying these disorders, it is postulated that immune dysregulation is associated with the formation of an immune niche that allows the formation and progression of lesions typical of endometriosis. When diagnosing and treating patients with endometriosis, one should not forget about the spectrum of comorbidities, some of which are serious diseases leading to numerous complications.

References

Harris, H.R., Costenbader K.H., Mu, F., et al. (2016a). Endometriosis and the risks of systemic lupus erythematosus and rheumatoid arthritis in the Nurses' Health Study II. Annals of the Rheumatic Diseases 75 (7), 1279-1284. https://doi.org/10.1136/annrheumdis-2015-207704. Harris, H.R., Simard, J.F., Arkema, E.V. (2016b). Endometriosis and systemic lupus erythematosus: a population-based case-control study, Lupus, 25 (9),1045-1049. https://doi.org/10.1177/0961203316631635. Katiyar, A., Sharma, S., Singh, T.P., Kaur, P. (2018). Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis, Frontiers in Genetics, 9, 42. https://doi.org/10.3389/fgene.2018.00042 Peyneau, M., Kavian, N., Chouzenoux S., i in. (2019). Role of thyroid dysimmunity and thyroid hormones in endometriosis, Proceedings of the National Academy of Sciences of the United States of America, 116 (24), 11894-11899. https://doi.org/10.1073/pnas.1820469116. Porpora, M.G., Scaramuzzino, S., Sangiuliano, C., Piacenti, I., Bonanni, V., Piccioni, M.G., Benedetti, Panici, P.L. (2019). High prevalence of autoimmune diseases in women with endometriosis: a case-control study, Gynecological Endocrinology, 36 (4), 356–359. https://doi.org/10.1080/09513590.2019.1655727. Maksym, R., Baranowski, W. (2020). Etiopatogeneza endometriozy – geny czy środowisko? (w:) W. Baranowski (red.), Standardy diagnostyki i leczenia endometriozy - Monografia Ginekologia po Dyplomie, 5-10, Warszawa: Medical Tribune Polska. Mormile, R., Vittori, G. (2013). Celiac disease and endometriosis: what is the nexus? Archives of Gynecology and Obstetrics, 288 (6), 1197-1198. https://doi.org/10.1007/s00404-013-2928-3. Mormile, R., Vittori, G. (2014). Endometriosis and susceptibility to multiple sclerosis: is there any absolute truth? European Journalof Obstetrics & Gynecology and Reproductive Biology, 179, 253. https://doi.org/10.1016/j.ejogrb.2014.04.044. Santoro, L., Campo, S., D'Onofrio F., i in. (2014). Looking for celiac disease in Italian women with endometriosis: a case control study, BioMed Research International, 236821. https://doi.org/10.1155/2014/236821. Shigesi, N., Kvaskoff, M., Kirtley S., i in. (2019). The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis, Human Reproduction Update, 25 (4), 486-503. https://doi.org/10.1093/humupd/dmz014.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK