Gene Chi Wai Man

No ORCID on file · 18 papers in corpus · active 2011-2026

Study types

  • article 9
  • other 3
  • review 3
  • book-chapter 2
  • preprint 1

Condition tags

  • endometriosis 16
  • mesh:D004715 9
  • infertility 2
  • dysmenorrhea 1
  • dyspareunia 1
article 2026
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis
Antioxidants (Basel, Switzerland) ·doi:10.3390/antiox15020159

Endometriosis is a hormone-dependent gynecological disease manifested by cyclic pelvic pain and female infertility. Although many studies have shown that neoangiogenesis plays an essential role in the development of early endometriosis, the…

preprint 2024
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis
·doi:10.2139/ssrn.4786240
other 2024
Unique anti-angiogenic effects, pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis
Genes & diseases ·doi:10.1016/j.gendis.2023.101166
article 2023
Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis
Journal of pharmaceutical analysis ·doi:10.1016/j.jpha.2023.09.005

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the uterus. Angiogenesis is a major pathophysiology in endometriosis. Our previous studies have demonstrated that the prodrug of epigallocate…

article 2023
Isolation of myeloid-derived suppressor cells (MDSC) from endometriotic mice model and their immunomodulatory functions
Methods in cell biology ·doi:10.1016/bs.mcb.2023.04.004
article 2023
Myeloid-derived suppressor cells: A new emerging player in endometriosis
International review of cell and molecular biology ·doi:10.1016/bs.ircmb.2022.11.004
review 2023
Therapeutic effects of green tea on endometriosis
Critical reviews in food science and nutrition ·doi:10.1080/10408398.2021.1986465

Endometriosis is a chronic disorder characterized by the presence of endometrial glands and stroma outside the uterine cavity. It affects 8%-10% of women in their reproductive years, and represents a major clinical problem with deleterious …

article 2022
Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry
Frontiers in pharmacology ·doi:10.3389/fphar.2022.1025053

(-)-Epigallocatechin-gallate octaacetate (pro-EGCG), a prodrug of epigallocatechin-gallate (EGCG), has been used for pre-clinical study for the treatment of endometriosis. A validated analytical method has been developed for the determinati…

review 2022
Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight
Nutrients ·doi:10.3390/nu14194087

Endometriosis is defined as the development of endometrial glands and stroma outside the uterine cavity. Pathophysiology of this disease includes abnormal hormone profiles, cell survival, migration, invasion, angiogenesis, oxidative stress,…

article 2018
MDSCs drive the process of endometriosis by enhancing angiogenesis and are a new potential therapeutic target
European journal of immunology ·doi:10.1002/eji.201747417

Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we fo…

review 2018
The link between immunity, autoimmunity and endometriosis: a literature update
Autoimmunity reviews ·doi:10.1016/j.autrev.2018.03.017
article 2015
Differential expression of vascular endothelial growth factor angiogenic factors in different endometrial compartments in women who have an elevated progesterone level before oocyte retrieval, during in vitro fertilization–embryo transfer treatment
·doi:10.1016/j.fertnstert.2015.06.021
article 2013
Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis
Angiogenesis ·doi:10.1007/s10456-013-9333-1
other 2012
Green Tea for Endometriosis
book-chapter 2012
Green Tea for Endometriosis
·doi:10.5772/28874

Endometriosis is a common gynaecological disease, defined by the presence of endometrial tissue outside the uterus, causing pain and infertility of women in reproductive age (Galle, 1989). It is estimated that it occurs in 10-15% for women …

book-chapter 2012
Pathophysiological Changes in Early Endometriosis
·doi:10.5772/31372

Endometriosis is one of most common gynecological disorder, but poorly understood condition. As early as in 1860, von Rokitansky (Rokitansky, 1860) is the first one to describe www.intechopen.com

article 2012
Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice
Angiogenesis ·doi:10.1007/s10456-012-9299-4
other 2011
Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.07.008

OBJECTIVE: To investigate the antiangiogenesis mechanism of epigallocatechin-3-gallate (EGCG) in an endometriosis model in vivo. DESIGN: Animal studies. SETTING: University laboratory. ANIMAL(S): Human endometrium from women with endomet…