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BackgroundDuring a stimulated cycle of in vitro fertilisation or intracytoplasmic sperm injection (IVF/ICSI), women receive daily doses of gonadotropin follicle-stimulating hormone (FSH) to induce multifollicular development in the ovaries.…
OBJECTIVES: To identify strategies used in recent randomized controlled trials (RCTs) and their associated Cochrane Reviews where patients with the same gynecological condition present with different symptoms but would plausibly benefit fro…
Abstract Objectives I dentify strategies used in the design of recent randomised controlled trials (RCTs) and their associated Cochrane reviews where patients with the same gynaecological condition present with different symptoms. Study Des…
Infertility randomized controlled trials (RCTs) are often too small to detect realistic treatment effects. Large observational studies have been proposed as a solution. However, this strategy threatens to weaken the evidence base further, b…
BackgroundHeavy menstrual bleeding (HMB) is excessive menstrual blood loss that interferes with women's quality of life, regardless of the absolute amount of bleeding. It is a very common condition in women of reproductive age, affecting 2 …
Study questionCan a core outcome set to standardize outcome selection, collection and reporting across future infertility research be developed?Summary answerA minimum data set, known as a core outcome set, has been developed for randomized…
Study questionsIn couples with unexplained infertility and a poor prognosis of natural conception, are four cycles of IUI with ovarian stimulation (IUI-OS) non-inferior to one completed cycle of IVF for the outcome of cumulative live birth?…
Study questionCan consensus definitions for the core outcome set for infertility be identified in order to recommend a standardized approach to reporting?Summary answerConsensus definitions for individual core outcomes, contextual statement…
STUDY QUESTION: Can the priorities for future research in infertility be identified? SUMMARY ANSWER: The top 10 research priorities for the four areas of male infertility, female and unexplained infertility, medically assisted reproduction…
IntroductionOne potential stressor that can affect preimplantation and postimplantation embryonic growth after in vitro fertilisation (IVF) is the pH of the human embryo culture medium, but no evidence exists to indicate which pH level is o…
Study questionsWe aim to produce, disseminate and implement a core outcome set for future infertility research.What is known alreadyRandomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes,…
BackgroundDuring a cycle of in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI), women receive daily doses of gonadotropin follicle-stimulating hormone (FSH) to induce multifollicular development in the ovaries. Generall…
This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To identify, systematically assess and summarise all evidence from Cochrane Reviews on treatment for heavy menstrual bleeding (HMB), through a network meta‐…
Study questionHow much variation in oocyte yield after controlled ovarian stimulation (COS) can be accounted for by known patient and treatment characteristics?Summary answerThere is substantial variation in the COS responses of similar wom…