Zhao X

BackgroundExisting biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker candi…

Serous papillary adenofibroma (SPAF) is a rare benign tumor in gynecological practice. Most patients have no symptoms and occasionally present with pelvic masses during physical examinations. SPAF consists of both fibrous and epithelial par…

Background and objectivePrimary dysmenorrhea carries substantial medical, social, and economic burdens, leading many patients to seek low-risk complementary and alternative therapies, such as acupuncture. Myofascial trigger point dry needli…

BackgroundOvarian sex cord-stromal tumors (OSCSTs) are a rare and heterogeneous group of ovarian neoplasms, encompassing various subtypes such as ovarian thecoma, fibroma (including cellular fibroma), and ovarian granulosa cell tumors (OGCT…

DNA and RNA nucleotide sequences are ubiquitous in all biological cells, serving as both a comprehensive library of capabilities for the cells and as an impressive regulatory system to control cellular function. The multi-alignment framewor…

BackgroundAcupuncture and moxibustion, as traditional therapies in Chinese medicine, are widely recognized for their therapeutic effects, particularly in pain relief. Nevertheless, the exact mechanisms underlying their analgesic effects rem…

High-resolution three-dimensional (3D) tissue analysis has emerged as a transformative innovation in the life sciences, providing detailed insights into the spatial organization and molecular composition of biological tissues. This review b…

Background: Endometriosis results in dysmenorrhea, dyspareunia, chronic pelvic pain and infertility in reproductive-age women. However, no effective treatment methods have been applied to the disease, and the pathogenesis of endometriosis i…

BackgroundCurrent therapeutic approaches for premature ovarian failure (POF) are often inadequate in clinical practice and some raise ethical concerns. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have emerged as a preferred optio…

BACKGROUND: Classification attempts and treatment strategies for endometriosis have been predominantly biomedical. Symptom profiles observed in individuals with endometriosis are multidimensional and may be more effectively captured by a bi…

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and have been shown to interfere with the endocrine system, leading to adverse effects on reproductive health. In females, EDC exposure has been linked to menstrual irr…

AimTo investigate the risk factors associated with postpartum urinary retention after cesarean section (CS) and to determine the associated morbidity rate.MethodsThis study was a population-based retrospective case-control study analyzed us…

BackgroundIntrauterine adhesions (IUAs) can easily cause female infertility or recurrent abortion, but there is still no effective treatment to improve the pregnancy and live birth rates in patients with IUAs. In recent years, great advance…

To explore and validate active components in the Yijing Decoction formula that exert therapeutic effects on targets associated with premature ovarian insufficiency (POI) and to identify the underlying mechanisms of action. A rat model of PO…

BackgroundLow-grade endometrial stromal sarcoma (LG-ESS) is a rare malignant tumor of the female reproductive system with atypical clinical symptoms and slow progression.CaseA 44-year-old female with a history of intermittent severe dysmeno…

ObjectiveAdvanced gastric cancer remains highly refractory to therapy, with limited immunotherapy efficacy due to tumor microenvironment heterogeneity. Primary cilia, microtubule-based organelles involved in tumor progression, remain insuff…

BACKGROUND: Triclosan, a widely used environmental contaminant with endocrine-disrupting properties, has been increasingly implicated in female reproductive disorders. However, the potential mechanistic link between triclosan exposure and e…

BACKGROUD: Ovarian aging can lead to early menopause, infertility, and even premature senility in female patients, seriously impairing the quality of life. Unfortunatly, it is still lack of effective protection strategies against ovarian ag…

Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis…

The reprogrammed osteogenic phenotype of vascular smooth muscle cells (VSMCs) is considered a critical mechanism of vascular calcification (VC) in chronic kidney disease (CKD). Currently, the RNA N6-methyladenosine (m6A) modification is dec…

MicroRNAs play crucial roles in regulating inflammatory responses and disease progression. Since its identification on chromosome 17q11.2 in 2005, miR-451 has emerged as a key regulator of multiple physiological and pathological processes. …

PURPOSE: The study aimed to develop a nomogram to predict live birth outcomes in infertile women with adenomyosis undergoing IVF/ICSI treatment. MATERIALS AND METHODS: Data were collected from the Center for Reproductive Medicine, Shandong…

BackgroundInflammatory Bowel Disease (IBD) is a chronic, idiopathic inflammatory disorder of the intestines. Oxymatrine (OMT) is a naturally active substance found in the desiccated roots of Sophora flavescens. It possesses anti-tumor, anti…

BackgroundPrevious studies have identified that exposure to heavy metals increases the prevalence of congenital heart defects (CHDs); however, limited information exists regarding the association between combined exposure to barium (Ba) and…

BackgroundTrophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast regulation remain poorly…