Izumi Kusuki

No ORCID on file · 42 papers in corpus · active 1999-2025

Study types

  • article 35
  • other 4
  • case-report 2
  • review 1

Condition tags

  • endometriosis 41
  • endometrioma 8
  • adenomyosis 5
  • chronic_pelvic_pain 2
  • infertility 2
  • die_deep_infiltrating 2
  • bladder_endometriosis 1
  • dyspareunia 1
  • dysmenorrhea 1
article 2015
G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.01.026
other 2014
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography-positive lymph node endometriosis masquerading as lymph node metastasis of a malignant tumor
Case reports in obstetrics and gynecology ·doi:10.1155/2014/648485

Endometriosis is defined as the presence of endometrium-like tissues at extrauterine sites, most commonly in the abdominal cavity. Lymph node endometriosis is a rare but clinically important type of endometriosis that can mimic lymph node m…

article 2014
Clear Cell Carcinoma Arising from Cesarean Section Scar Endometriosis: Case Report and Review of the Literature
Case reports in obstetrics and gynecology ·doi:10.1155/2014/642483

Introduction. The incidence of endometriosis affecting skin tissue represents only 0.5-1.0% of all endometriosis cases. A malignancy in the abdominal wall arising from endometriosis following cesarean section is even rarer; only 21 cases ha…

article 2014
ISAC-4-3 Stimulation of Aromatase by Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha (PGC-1α) in Endometriosis(Group 4 Reproduction,IS Award Candidate,International Session)
article 2014
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2013-2525

CONTEXT: Endometriosis is an estrogen-dependent disease, and estrogen is overproduced by abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated receptor gamma, coactivator 1α (PGC-1α) is a transcriptional …

article 2012
Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2012.08.023
article 2012
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.11.005
article 2011
Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2011.03.012
article 2010
IS-20 Frequent loss of heterozygosity in ovarian cancer arising from endometriosis : possible involvement in malignant transformation(Group2 Oncology2,International Session) :
article 2010
Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis
Gynecologic oncology ·doi:10.1016/j.ygyno.2010.10.036
article 2002
Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women
Human Reproduction ·doi:10.1093/humrep/17.4.897

BACKGROUND: To investigate whether polymorphisms of CYP17 and CYP19 genes are associated with the risk of endometriosis, we analysed the frequency and distribution of a single nucleotide polymorphism at the 5' untranslated region of the CYP…

other 2002
Genetic contribution of the interleukin-10 promoter polymorphism in endometriosis susceptibility
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1034/j.1600-0897.2002.1o029.x

PROBLEM: Interleukin-10 (IL-10) is an important immunomodulatory cytokine. The aim of this study was to investigate whether polymorphisms of the IL-10 gene promoter polymorphisms may be responsible in part for genetic susceptibility to endo…

article 2001
[Hormone responsiveness of endometriosis].
Nihon rinsho. Japanese journal of clinical medicine
article 2001
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/s0301-2115(01)00288-3
article 2000
Progesterone Induction of 17β-Hydroxysteroid Dehydrogenase Type 2 during the Secretory Phase Occurs in the Endometrium of Estrogen-Dependent Benign Diseases But Not in Normal Endometrium
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.85.9.6829

In the human endometrium, inactivation of 17beta-estradiol to estrone is catalyzed by 17beta-hydroxysteroid dehydrogenase type 2 (17betaHSD2). Previous studies have shown that the 17betaHSD2 activity in the endometrium is elevated during th…

article 1999
Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(99)00424-0
review 1999
Expression of Aromatase Cytochrome P450 in Eutopic Endometrium and Its Application as a Diagnostic Test for Endometriosis
Gynecologic and obstetric investigation ·doi:10.1159/000052865

Endometriotic implants, like other estrogen-dependent tumors, contain both estrogen receptors and aromatase cytochrome P450 (P450arom), suggesting that at a local level, endometriotic implants produce estrogens, which may be involved in tis…