Kohan-Ghadr HR

No ORCID on file · 4 papers in corpus · active 2016-2017

Condition tags

  • infertility 1
2017
Cyclophosphamide and acrolein induced oxidative stress leading to deterioration of metaphase II mouse oocyte quality.
Free radical biology & medicine ·doi:10.1016/j.freeradbiomed.2017.05.006

Cyclophosphamide (CTX) is a chemotherapeutic agent widely used to treat ovarian, breast, and hematological cancers as well as autoimmune disorders. Such chemotherapy is associated with reproductive failure and premature ovarian insufficienc…

2017
Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure.
Scientific reports ·doi:10.1038/s41598-017-00159-y

Premature ovarian insufficiency (POI) is a frequent long-term complication of classic galactosemia. The majority of women with this disorder develop POI, however rare spontaneous pregnancies have been reported. Here, we evaluate the effect …

2016
Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dew143

Study questionIs protein expression of the muscle segment homeobox gene family member MSX1 altered in the human secretory endometrium by cell type, developmental stage or fertility?Summary answerMSX1 protein levels, normally elevated in the…

2016
The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality.
PloS one ·doi:10.1371/journal.pone.0151160

Myeloperoxidase (MPO), an abundant heme-containing enzyme present in neutrophils, monocytes, and macrophages, is produced in high levels during inflammation, and associated with poor reproductive outcomes. MPO is known to generate hypochlor…