Ma J

PurposeTo identify the specific risk factors associated with unexplained infertility (UI) among infertile couples.MethodsWe conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who completed t…

ObjectiveTo evaluate the impact of day 4 double embryo transfer (DET) with a fully compacted morula (FCM) and a partially compacted morula (PCM) versus day 4 single embryo transfer (SET) with an FCM on clinical and neonatal outcomes in fres…

ObjectiveThe aim of this retrospective cohort study was to evaluate the clinical and neonatal outcomes between day 4 and day 5 embryo transfer across different fertilization methods.MethodsThis retrospective cohort study was conducted betwe…

Environmental estrogens, a group of exogenous endocrine-active compounds, are frequently present in animal feed, water, and husbandry environments. These compounds, which include synthetic xenoestrogens, phytoestrogens, and metalloestrogens…

Leuprolide and Goserelin, both gonadotropin-releasing hormone (GnRH) agonists, are commonly used for ovarian function suppression and the management of hormone-dependent cancers. However, systematic comparisons of their adverse event (AE) p…

Di(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer and endocrine disruptor that can impair ovarian function by provoking oxidative stress, mitochondrial injury, and apoptosis in granulosa cells. Lycopene is a diet-derived carote…

This study builds upon existing research achievements in bioinformatics to systematically screen a comprehensive set of biomarkers and prognostic models associated with immune infiltration regulation in the tumor microenvironment of endomet…

Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic chemicals notable for their high persistence and extensive applications. With the advancement of detection technologies in recent years, PFAS have been frequently identifie…

BACKGROUND: Endometriosis, a chronic immune-mediated inflammatory disease, remains elusive in its pathogenesis. Given vitamin D (VD)'s pivotal role in modulating innate and adaptive immune responses, we sought to elucidate how VD modulates …

Multifunctional small-molecule theranostic agents hold significant clinical potential for non-invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy-associated side e…

Abstract Background: Ovarian sex cord-stromal tumors are rare neoplasms originating from the sex cords and stromal tissue of the ovary, with extraovarian occurrences being even rarer in clinical settings. In this report, we describe a case…

IntroductionThe burden of gynaecological diseases is increasing globally, affecting women's health, quality of life and fertility. Improving the quality of gynaecological care will enhance patient recovery and improve outcomes of gynaecolog…

Epithelial-myoepithelial carcinoma (EMC) of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Breast epithelial myoepithelial carcinoma lacks therapeutic strategies due to its rari…

BACKGROUND: Female reproductive diseases-including endometriosis (EMs), uterine fibroids (UFs), polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), eclampsia, ectopic pregnancy (EP), infertility, miscarriage, and ovarian …

PURPOSE: To investigate the impact of changing to the PPOS protocol in the population with a premature progesterone increase (≥ 0.9 ng/mL) from the antagonist protocol on the clinical outcomes. METHODS: The study was a retrospective cohort,…

Chronic widespread pain (CWP) remains challenging due to its heterogeneous causes and complex mechanisms. A total of 2920 plasma proteins are analyzed from 29,254 UK Biobank participants. A total of 256 proteins are identified as cross-sect…

BackgroundWith the development of society, fertility seems to have become a public health issue in East Asian countries. At present, there is insufficient attention to infertility, especially male infertility. Understanding the burden and t…

BackgroundAssisted reproductive technology (ART) effectively treats infertility yet often results in multiple pregnancies. Optimizing clinical pregnancy rates while minimizing multiples remains challenging. Key considerations for ART provid…

BackgroundThe echo pattern constitutes an ultrasonic index that reflects the characteristics of the endometrium across various phases of the menstrual cycle. However, consensus of endometrial echo pattern and pregnancy outcomes is lacking i…

BackgroundUterine artery embolization (UAE) is a vital treatment modality for various gynecological conditions. However, complications may arise from the accidental migration of embolic agents into non-target tissues through the uterine art…

BACKGROUND: Acute pancreatitis (AP) can be mild and self-limited, but it can also become severe acute pancreatitis (SAP) and lead to multi-organ dysfunction. It is still difficult to identify patients who may develop severe disease at an ea…

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging ha…

Endometriosis (EMS) is a prevalent gynecological disease afflicting reproductive-age women, characterized by the presence of endometrial tissue outside the uterus. The clinical manifestations of this condition include pelvic pain, dyspareun…

Inflammation is a multifaceted defense mechanism of the immune system against infection. Chronic inflammation is intricately linked to all stages of tumorigenesis and is therefore associated with an elevated risk of developing serious cance…

Endometriosis affects a substantial number of women of reproductive age, yet current diagnostic methods rely on invasive procedures. To address this limitation, we investigated THBS1 as a potential biomarker and regulator of disease progres…