THBS1 identificated as an endometriosis biomarker through evidence from single-cell and bulk transcriptomic profiling

Liqi Zhang, Junyan Ma, Yuhui Sun, Jue Zhu, Huaqing Yan, Yichen Chen, Jing Zhang
iScience · 2025 · vol. 28(12) , pp. 114164 · doi:10.1016/j.isci.2025.114164 · PMID:41438033 · W7106243534
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study identified THBS1 as a potential endometriosis biomarker by analyzing single-cell and bulk transcriptomic data, linking its molecular activity to the disease's pathophysiology.

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Abstract

. These findings position THBS1 as a central modulator of endometrial cellular behavior and provide a conceptual framework linking its molecular activity to the pathophysiology of endometriosis. The study supports THBS1 as a candidate biomarker that could inform the development of noninvasive diagnostic strategies.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

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