NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis

Xinliu Zeng, Zeng X, Zhang Yue, Yue Z, Yue Zhang, Ying Gao, Gao Y, Jiang G, Guosong Jiang, Zeng F, Fuqing Zeng, Ying Shao, Shao Y, Jiayu Huang, Huang J, Yin M, Minuo Yin, Yajie Li, Li Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018 · vol. 46(3) , pp. 1078–1090 · doi:10.1159/000488838 · PMID:29669342 · W2803033855
article OA: gold CC0 ⤵ 19 in-corpus citations
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Phosphorylated NR4A1 levels are elevated in ovarian endometriosis, and NR4A1 inhibition promotes fibrosis, suggesting it regulates fibrogenesis and is a potential therapeutic target.

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Abstract

BACKGROUND/AIMS: Excess fibrosis may lead to chronic pain, scarring, and infertility as endometriosis develops and progresses. The pathogenesis of endometriosis has been linked to transforming growth factor-β (TGF-β), the most potent promoter of fibrosis. METHODS: Levels of NR4A1 and P-NR4A1 protein in human endometrial and endometriotic tissue were assessed by western blotting and immunohistochemistry. The expression levels of fibrotic markers in stromal cells were evaluated by real-time PCR. The degree of fibrosis in mouse endometriotic lesions was detected by Masson trichrome and Sirius red staining. RESULTS: The level of phosphorylated-NR4A1 was higher in ovarian endometriotic tissue than in normal endometrium, and long-term TGF-β1 stimulation phosphorylated NR4A1 in an AKT-dependent manner and then promoted the expression of fibrotic markers. Furthermore, inhibition of NR4A1 in stromal cells increased the TGF-β1-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis. Additionally, Cytosporone B (Csn-B), an NR4A1 agonist, effectively decreased the TGF-β1-dependent elevated expression of fibrotic markers in vitro and significantly inhibited fibrogenesis in vivo. CONCLUSION: NR4A1 can regulate fibrosis in endometriosis and may serve as a new target for the treatment of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Nuclear Receptor Subfamily 4, Group A, Member 1 Adult Animals Cells, Cultured Collagen Type I Collagen Type I Collagen Type I Collagen Type I, alpha 1 Chain Connective Tissue Growth Factor Connective Tissue Growth Factor Connective Tissue Growth Factor Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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