Jiayu Huang

ORCID: 0000-0001-5195-1330 · 4 papers in corpus
lab-animal 2025
Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-025-01428-6

BACKGROUND: The quality of in vitro matured (IVM) oocytes remains inferior to that of in vivo matured oocytes, likely due to DNA damage induced by the in vitro environment. Although rapamycin has been shown to improve the developmental comp…

lab-animal 2022
TOP2A deficit-induced abnormal decidualization leads to recurrent implantation failure via the NF-κB signaling pathway
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-01013-1

BACKGROUND: Successful implantation is a complex process that is influenced by embryo quality, endometrial receptivity, immune factors, and the specific type of in vitro fertilization protocol used. DNA topoisomerase IIα (TOP2A) is a well-k…

lab-animal 2021
Long non-coding RNA lnc-CCNL1-3:1 promotes granulosa cell apoptosis and suppresses glucose uptake in women with polycystic ovary syndrome
Molecular therapy. Nucleic acids ·doi:10.1016/j.omtn.2020.12.008

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in premenopausal women. Long non-coding RNAs (lncRNAs) constitute important factors in numerous biological processes. However, their roles in PCOS pathogenesis req…

lab-animal 2018
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology ·doi:10.1159/000488838

BACKGROUND/AIMS: Excess fibrosis may lead to chronic pain, scarring, and infertility as endometriosis develops and progresses. The pathogenesis of endometriosis has been linked to transforming growth factor-β (TGF-β), the most potent promot…