Einleitung: Frauen mit Endometriose haben ein erhöhtes Risiko, später ein endometrioides oder klarzelliges Ovarialkarzinom zu entwickeln. Falls Endometriosepatientinnen zusätzlich unter langjähriger Infertilität leiden, erhöht sich die Stan…
We explored the association of the PPAR-gamma2 (peroxisome proliferator-activated receptor) Pro-12-Ala polymorphism with endometriosis in a case-control study with 51 women with endometriosis stages I-IV and 55 control women without endomet…
Cytokines are important mediators of intercellular communication within the immune system. They target a variety of cells and show proliferative, chemoattractant, differentiative, or cytostatic effects. Most cytokines are coupled to intrace…
Die Behandlung der Endometriose konzentriert sich auf zwei Hauptziele: die Verringerung von Schmerzen und die Therapie der Infertilität. Die Schmerztherapie bei Endometriose wurde bisher gut untersucht. So waren alle medikamentösen Behandlu…
Eine erhöhte Anzahl von aktivierten Peritonealmakrophagen, die durch Chemokine angezogen werden, sind ein wichtiges pathophysiologisches Merkmal für Frauen mit Endometriose. In dieser Studie charakterisieren wir die inflammatorische Antwort…
Chemoattraction of macrophages into the peritoneal cavity is one of the important characteristics in patients with endometriosis. An inflammatory response is postulated to be responsible for infertility and pelvic pain associated with this …
Die Migration von Makrophagen in die Peritonealhöhle ist ein wesentlicher pathophysiologischer Faktor der Endometriose. Frühere Daten aus unserem Labor deuteten darauf hin, dass RANTES (Regulated on Activation, Normal T cell Expressed and S…
Endometriotic lesions secrete chemokines that recruit immune cells into the peritoneal cavity. The accumulation of these immune cells, especially activated macrophages and T lymphocytes, is thought to mediate inflammatory symptoms associate…
The human endometrium is a complex tissue comprised of different cell types, including epithelial, stromal, inflammatory, perivascular, and blood vessel cells. The hormonal receptivity and distribution of these cell populations change durin…
OBJECTIVE: The immunological mechanisms that support persistence and proliferation of ectopic endometrial implants within the peritoneal cavity of women with endometriosis are unknown. Inhibition of natural killer (NK) and cytotoxic T-cell …
The peroxisome proliferator-activated receptors (PPARs) alpha and gamma are nuclear receptors that play important roles in inflammatory diseases like ulcerative colitis and arthritis. In this study, we examined the possible role of PPARs in…
Chemoattraction of macrophages and T cells into the normal endometrium and inflammatory sites within endometriotic foci is mediated by chemokine gene expression. mRNA transcripts encoding regulated on activation, normal T-cell-expressed and…
The peroxisome proliferator-activated receptors (PPARs) � and � are nuclear receptors that play important roles in inflammatory diseases like ulcerative colitis and arthritis. In this study, we examined the possible role of PPARs in macroph…
Our laboratories have focused recently on the production and localization of eotaxin, a C-C-chemokine of 8.4 kDa, whose major biological activity is the chemoattraction of eosinophils. Given evidence of autoimmune activity in the endometrio…
The assessment of the activity of endometriosis provides a challenge during endoscopic procedures. Novel approaches can be developed in future based on more detailed understanding of the mechanisms of the pathogenesis of endometriosis. Angi…