Binkley PA

No ORCID on file · 12 papers in corpus · active 2005-2020

Study types

  • article 10
  • other 2

Condition tags

  • endometriosis 11
article 2020
Inhibition of Hyaluronic Acid Synthesis Decreases Endometrial Cell Attachment, Migration, and Invasion
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-019-00100-w

To characterize the effects of 4-methylumbelliferone (4-MU) on expression of the hyaluronic acid (HA) system and on attachment, migration, and invasion of endometrial epithelial (EECs) and stroma cells (ESCs) to peritoneal mesothelial cells…

article 2018
The Hyaluronic Acid System is Intact in Menstrual Endometrial Cells in Women With and Without Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719118766257

ObjectiveTo characterize the production and degradation of hyaluronic acid (HA) in menstrual endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) in women with and without endometriosis. To identify the presence of CD44,…

article 2015
Impaired Development of Early Endometriotic Lesions in CD44 Knockout Mice
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115594022

Previous studies have shown endometrial cell (EC) CD44 and peritoneal mesothelial cell (PMC)-associated hyaluronan (hyaluronic acid [HA]) are involved in the attachment of endometrial stroma and epithelial cells to peritoneal mesothelium. H…

article 2012
Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.02.007

ObjectiveTo investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis.DesignIn vivo and vitro study.SettingUniversity-based academic medical center.Patient(s)Reproductive-age …

article 2012
Raf-1, a Potential Therapeutic Target, Mediates Early Steps in Endometriosis Lesion Development by Endometrial Epithelial and Stromal Cells
Endocrinology ·doi:10.1210/en.2011-1879

Endometriosis is a hormone-sensitive gynecological disorder characterized by the benign growth of endometrial-like tissue in the pelvic cavity. Endometriotic lesions composed of endometrial stromal cells (ESC) and glandular epithelial cells…

article 2011
Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.03.026

Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion format…

other 2011
Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.09.005

The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expressi…

article 2010
Imatinib decreases endometrial stromal cell transmesothial migration and proliferation in the extracellular matrix of modeled peritoneum
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.04.018

ObjectiveTo characterize imatinib's effect on endometrial stromal cell (ESC) attachment, proliferation, and invasion in modeled peritoneum.DesignIn vitro study.SettingAcademic medical center.Patient(s)Twelve normally cycling women.Intervent…

article 2009
Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta
Molecular human reproduction ·doi:10.1093/molehr/gap043

Transforming growth factor beta 1 (TGF-beta1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-beta signaling components; however, little is known regarding the role of TGF-beta in en…

article 2009
Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.12.012

ObjectiveWe previously demonstrated that adherence of endometrial epithelial (EECs) and stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) is partly regulated by ESC/EEC CD44 interactions with PMC associated hyaluronan. CD44, a tra…

article 2009
Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion
Molecular human reproduction ·doi:10.1093/molehr/gap061

The aim of this study was to investigate whether peroxisome proliferator-activated receptor (PPAR)-gamma activation has an effect on the attachment of endometrial cells to peritoneal mesothelial cells in a well-established in vitro model of…

other 2005
A novel in vitro model of the early endometriotic lesion demonstrates that attachment of endometrial cells to mesothelial cells is dependent on the source of endometrial cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2004.10.058

OBJECTIVE: To characterize the source of variability in endometrial stromal cell (ESC) binding to peritoneal mesothelial cells (PMC). DESIGN: In vitro study. SETTING: University medical center. PATIENT(S): Reproductive-age women without …