Otsuka J

No ORCID on file · 4 papers in corpus · active 2003-2004

Study types

  • article 3
  • review 1

Condition tags

  • endometriosis 3
article 2004
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma
Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan ·doi:10.1007/s00795-004-0252-5

Endometriosis shares some features characteristic of malignancy; however, it remains unclear whether endometriosis is a precursor to malignant disease. The objective is to determine the genetic relationship between endometriosis and ovarian…

article 2004
Malignant transformation of endometriosis and genetic alterations of K‐ras and microsatellite instability
International Journal of Gynecology & Obstetrics ·doi:10.1016/j.ijgo.2004.04.036

OBJECTIVES: To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis. METHODS: In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypi…

review 2004
Malignant transformation of endometriosis: application of laser microdissection for analysis of genetic alterations according to pathological changes
Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan ·doi:10.1007/s00795-003-0233-0

Endometriosis is considered to be a possible precancerous disease. Pathologically, we observed malignant transformation of endometriosis to clear cell carcinoma or endometriotic carcinoma of the ovary, via the step of atypical endometriosis…

article 2003
p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer
Gynecologic oncology ·doi:10.1016/s0090-8258(02)00149-x

ObjectiveAlthough ovarian clear cell adenocarcinoma (OCCA) and ovarian endometrioid adenocarcinoma (EC) are considered to be closely related to endometriosis, the mechanisms of carcinogenesis of these two malignancies and malignant transfor…