Cedars MI

PurposeTo assess whether the endometrial receptivity analysis (ERA) captures receptivity changes attributed to endometrial aging and whether it may be useful for older patients undergoing fertility treatment.MethodsRetrospective cohort stud…

ObjectiveTo investigate if a positive result on ReceptivaDx for evaluation of B-cell lymphoma 6 (BCL6), a proposed marker of progesterone resistance associated with impaired uterine receptivity, correlates with a suboptimal profile of recep…

OBJECTIVE: To determine whether B-cell lymphoma 6 (BCL6), an endometriosis-associated marker postulated to predict poor pregnancy outcomes, is differentially expressed in the window of implantation with various uterine preparation regimens …

PurposeTo determine whether concomitant tamoxifen 20 mg with gonadotropins (tamoxifen-gonadotropin) versus letrozole 5 mg with gonadotropins (letrozole-gonadotropin) affects mature oocyte yield.MethodsOpen-label, single-institution, randomi…

PurposeTo determine the frequency of and factors associated with a patient being declined from pursuing a cycle of in vitro fertilization with autologous oocytes (IVF-AO).MethodsA cross-sectional study using a nationwide cohort of female re…

ContextThe relationship between reproductive and cardiometabolic aging is unclear. It is unknown if the relationship differs across different clinical populations.ObjectiveTo determine whether markers of ovarian reserve are associated with …

Changes in pituitary-ovarian hormones across the menopausal transition have multiple physiological consequences. However, little is known about how the major types of postmenopausal hormone therapy (HT) affect pituitary-ovarian hormonal rel…

Study questionDoes the interval from delivery to initiation of a subsequent ART treatment cycle impact clinical pregnancy or live birth rates?Summary answerAn interval from delivery to treatment start of <6 months or ≥24 months is associate…

BackgroundBecause the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian foll…

Study questionDoes the fertility status of an individual act as a biomarker for their future health?Summary answerData support an association between reproductive health and overall health for men and women.What is already knownVarious chro…

ObjectiveTo identify markers of ovarian age that best match the pattern of oocyte loss seen in histology specimens.DesignCross-sectional study.SettingUniversity.Patient(s)Caucasian women (n = 252) aged 25-45 years.Intervention(s)none.Main o…

Oocyte loss has a significant impact on fertility and somatic health. Yet, we know little about factors that impact this process. We sought to identify genetic variants associated with ovarian reserve (oocyte number as measured by antral fo…

BackgroundThe ovarian reserve (number and quality of oocytes) is correlated with reproductive potential as well as somatic health, and is likely to have multiple genetic and environmental determinants. Several reproductive hormones are clos…

ObjectiveTo determine whether infertile women have lower antral follicle counts (AFC) than age-matched normal women.DesignCase-control.SettingAcademic center.Patient(s)A total of 881 infertile women and 771 women from the community.Interven…

OBJECTIVE: To analyze the efficacy and cost-effectiveness of alternative treatments for unexplained infertility. DESIGN: Retrospective analysis of 45 published reports. SETTING: Clinical practices. PATIENT(S): Couples who met criteria for u…

OBJECTIVE: To examine possible adverse effects on pituitary function of long-term administration of gonadotropin-releasing hormone agonist (GnRH-a). DESIGN: Prospective analysis of blood sampling before, during, and after GnRH-a therapy. …

Highly potent agonists of gonadotropin-releasing hormone (GnRH) have been shown to reduce pelvic pain due to endometriosis and the size and number of implants seen at laparoscopy. The accompanying symptoms and problems associated with the h…