Pituitary function before, during, and after chronic gonadotropin-releasing hormone agonist therapy

M I Cedars, Cedars MI, Steingold KA, K A Steingold, Lu JH, J H Lu, Judd HJ, H J Judd, D R Meldrum, Meldrum DR
Fertility and sterility · 1992 · doi:10.1016/s0015-0282(16)55551-4 · PMID:1459255
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A prospective analysis of twelve women with endometriosis found that six months of gonadotropin-releasing hormone agonist therapy did not adversely affect pituitary function, as basal and stimulated hormone levels remained normal.

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Abstract

OBJECTIVE: To examine possible adverse effects on pituitary function of long-term administration of gonadotropin-releasing hormone agonist (GnRH-a). DESIGN: Prospective analysis of blood sampling before, during, and after GnRH-a therapy. SETTING: Tertiary institutional outpatient care. PATIENTS: Twelve normally ovulatory women with a diagnosis of endometriosis. INTERVENTIONS: Six-month suppression with GnRH-a. MAIN OUTCOME MEASURES: Serum levels of follicle-stimulating hormone, luteinizing hormone, free thyroxin index, cortisol (F), growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH). RESULTS: Basal and stimulated values of gonadotropins, PRL, F, TSH, and GH were normal and unchanged by 6 months of GnRH-a after resumption of menses. CONCLUSIONS: Utilizing dynamic pituitary function tests, we were unable to demonstrate an adverse effect of long-term GnRH-a therapy on pituitary function.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Pituitary Gland Adult Endometriosis Endometriosis Female Follicle Stimulating Hormone Follicle Stimulating Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Growth Hormone Growth Hormone Humans Hydrocortisone Hydrocortisone Luteinizing Hormone Luteinizing Hormone Pituitary Gland Prolactin

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