Hee Dong Chae

Endometriosis is defined as the presence of functional endometrial tissue outside the uterus, causing diverse progressive symptoms such as infertility, pelvic pain, and dysmenorrhea. Although endometriosis has been described since the 1800s…

We performed the present prospective case-control study to evaluate whether the plasma concentrations of phthalate esters are elevated in women with advanced-stage endometriosis in a Korean population. Measuring plasma levels of monoethylhe…

Hee Dong Chae, Peter Kraemer, Jeff Hassall, Pirjo Inki, Jens Ulrich Hanisch, Jungeun Lee Dept. of OBGY, Asan Medical Center, Ulsan University, Korea, Unibsteteric Gyayer HealthCare, Asia Pacific Women’s Healthcare, Singapore; Bayer HealthCa…

We evaluated whether the proinflammatory cytokines can regulate p21-activated kinase (Pak1) expression in endometrial cells as well as whether its expression is increased in endometriotic cysts. We found that interleukin-1β up-regulates Pak…

The present study was designed to evaluate whether the expression of p21-activated kinase 1 (Pak1), which recently has been shown to be increased in the eutopic endometrium of women with endometriosis, is also increased in adenomyotic nodul…

Based on the findings of several reports that have shown an increased plasma level of di-(2-ethylhexyl) phthalate (DEHP) in women with endometriosis, the present study was designed to evaluate whether in vitro treatment with DEHP can increa…

Endometriosis is a long term, disabling condition and a relatively common disease, affecting 5~15% of the adult female population.

BACKGROUND: P21-activated kinase 1 (Pak1) integrates various signaling pathways that are vital to cell survival and function. This study was performed to evaluate whether sex steroids may regulate the expression of Pak1 in endometrial cells…

PROBLEM: The intracellular antioxidant system, based on glutathione (GSH), plays a key role in endometrial detoxification reactions and has been proposed to be involved in the pathogenesis endometriosis. This study was designed to evaluate …

Angiogenin, a potent inducer of angiogenesis, is expressed in human endometrium. This study was performed to compare the expression of angiogenin mRNA level in the eutopic endometrium from women with and without endometriosis. Thirty-two wo…

Objective: This study was performed to investigate the expression of cathepsin B mRNA and Protein in eutopic and ectopic endometrial tissues of patients with endometriosis and in normal endometrial tissues, to compare the expression respect…

We report an unusual case in which a rapidly growing adenomyosis was identified during the first trimester in a 35-year-old infertile woman achieving pregnancy after controlled ovarian hyperstimulation. Relevant images are shown by magnetic…

Objective: This study was designed to investigate the association between C(-634)G polymorphism in the promotor region of vascualr endothelial growth factor (VEGF) and endometriosis. Methods: The genomic DNA was extracted from 100 patients …

Objective: To compare the expression of epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF-2) in the eutopic endometrium of women with and without endometriosis. Methods: Thirty-two women with histologically confirmed endomet…

목적 : 본 연구는 자궁내막증 환자의 이소성 자궁내막과 정상 위치의 자궁내막 그리고, 자궁내막증이 없는 환자의 자궁내막에서 혈관내피성장인자 수용체 (vascular endothelial growth factor receptor, VEGFR) 의 발현정도를 비교하기 위하여 시행되었다. 연구 방법 : 양성 부인과 질환의 수술적 치료를 통하여, 자궁내막증으로 확인된 환자들을 실험군으로 하였으며, 자궁내막증이 없는 환자들을 대조군으…

목적 : 국내에서 생산되고 있는 저장 형태의 성선자극호르몬 유리호르몬 동족체, leuprorelin acetate 제제인 로렐린(R)의 자궁내막증 치료에 있어서의 임상적 효용성과 안전성을 평가하기 위하여 시행되었다. 연구 대상 및 방법 : 수술시 자궁내막증으로 확진된 자궁내막증 환자 20명을 대상으로 약 21주간 추적 관찰하였다. 수술 직후 로렐린(R) 3.75 mg을 피하주사한 후 4주 간격으로 6차례에 걸쳐서 피하주사하였다…

OBJECTIVE: To compare the angiogenic activities of endothelial cells in the eutopic endometrium of women with and without endometriosis. DESIGN: Vessels with active angiogenesis were identified using the monoclonal antibody to endoglin. S…