Zhu Q

ObjectiveThe analgesic efficacy and safety of transversus abdominis plane block (TAPB) and thoracic paravertebral block (TPVB) were compared following laparoscopic total hysterectomy (LTH), and whether their treatment effects differ by frai…

Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease) upregulation in ovarian can…

ObjectiveTo evaluate the cost-effectiveness of the levonorgestrel intrauterine system (LNG-IUS) compared with hysteroscopic niche resection (HNR) for women with niche-related postmenstrual spotting.DesignEconomic evaluation from a healthcar…

RESEARCH QUESTION: Does peritoneal iron overload drive fibrosis in endometriosis through Nrf2 pathway dysfunction and the resulting ferroptosis, and can electroacupuncture intervene in this process? DESIGN: An endometriosis mouse model was…

In brief: Iron overload-induced ferroptosis contributes to ovarian damage in endometriosis, yet effective interventions are lacking. This study shows that electroacupuncture preserves ovarian function by activating the nuclear factor erythr…

Endometriosis diagnosis is often limited by the resolution of conventional imaging techniques (ultrasound/non-targeted MRI) as well as the invasiveness and recurrence risks associated with laparoscopy. To overcome these challenges, we devel…

BACKGROUND: The optimal interpregnancy interval (IPI) before reinitiating frozen-thawed embryo transfer (FET) after pregnancy loss remains uncertain, particularly in women undergoing assisted reproductive technology. Current guidelines reco…

RESEARCH QUESTION: Do iron metabolism and ferroptosis influence oocyte and embryo quality in patients with endometriosis undergoing IVF/intracytoplasmic sperm injection (ICSI), or in a mouse model? DESIGN: Fifty-seven patients with laparos…

BackgroundPreeclampsia is a severe hypertensive disorder with rising global prevalence. While machine learning (ML) models for predicting preeclampsia are increasingly published, existing evidence shows high heterogeneity, and the distincti…

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

Female reproductive disorders influence women's physical and mental well-being, and the sustainability of the family. However, it is unclear whether lifestyle factors, including sedentary behaviors and physical activity, could impact them. …

PurposeTo investigate the impact of regressed endometrial hyperplasia (EH) on assisted reproductive technology outcomes, particularly in comparison with infertile women with a relatively normal endometrium.MethodsThis retrospective study in…

Endometriosis (EMs) is an estrogen-dependent inflammatory disease characterized by the presence of endometrial-like tissue outside the uterine cavity, yet its precise pathogenesis remains incompletely elucidated. TICAM1, a key adaptor prote…

Abstract Endometriosis (EMS) is a chronic and refractory disease affecting women of reproductive age, and it carries an increased risk of developing endometriosis-associated ovarian cancer (EAOC). Currently, highly specific biomarkers are …

Diagnosing ovarian lesions is challenging because of their heterogeneous clinical presentations. Some benign ovarian conditions, such as endometriosis, can have features that mimic cancer. We use optical-resolution photoacoustic microscopy …

BackgroundIn assisted reproductive technology, preventing premature ovulation is crucial for achieving successful pregnancy outcomes. The traditional GnRH antagonist protocol is commonly used to suppress the luteinizing hormone (LH) surge, …

We present an extremely rare heterotopic pregnancy (HP) in a 33-year-old patient with multiple adenomyosis surgeries and bilateral salpingectomy, who conceived via assisted reproductive technology (ART). According to a review of the literat…

Ovarian-adnexal lesions are conventionally assessed with ultrasound (US) under the guidance of the Ovarian-Adnexal Reporting and Data System (O-RADS). However, the low specificity of O-RADS results in many unnecessary surgeries. Here, we us…

Abstract Background Endometriosis (EMs) often leads to ovarian dysfunction and infertility. Its mechanism is closely associated with oxidative stress and ferroptosis induced by pelvic iron overload. Electroacupuncture (EA) has potential i…

Adenomyosis, characterized by clinical intractability, significantly impacts female fertility and life quality due to the absence of definitive diagnostic markers and effective treatment options. The invagination theory is a primary hypothe…

Thin endometrium (TE, ≤7 mm) is widely recognized as a critical cause of infertility, recurrent pregnancy losses, and placental abnormalities. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a crucial role in tissue repair, …

Background: Oxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, …

IntroductionEndometrial receptivity (ER), critical for successful embryo implantation and a major limiting factor in infertility affecting ∼1 in 6 couples globally, remains poorly understood, with few effective interventions targeting the e…

INTRODUCTION: Dynamic changes in adenomyotic lesions in animal models have been difficult to observe and evaluate in vivo on a regular basis. Therefore, this study aims to investigate the feasibility of establishing a rat model of adenomyos…