William S.B. Yeung

ORCID: 0000-0003-0670-0879 · 17 papers in corpus · active 1992-2025

Study types

  • article 14
  • preprint 2
  • review 1

Condition tags

  • endometriosis 7
  • infertility 3
  • disambig:endometritis 1
article 2025
Abstract A075: Elucidating the endometrial epithelial cell origin of ovarian clear cell carcinoma with integrated multi-omics analysis
·doi:10.1158/1538-7445.ovarian25-a075

Abstract Introduction: Ovarian clear cell carcinoma (OCCC) is the second most common histological subtype of epithelial ovarian cancer (EOC), accounting for 5–25% of cases, with higher prevalence in East Asian populations. A significant pro…

article 2025
A single-cell multi-omic atlas of human endometrium with chronic endometritis reveals associated diagnostic signatures
·doi:10.1016/j.jri.2025.104718
preprint 2025
Drug-free In Situ Activation of Follicle through Laparoscopic Ovarian Cortical Incisions in Patients with Premature Ovarian Insufficiency
·doi:10.21203/rs.3.rs-7378665/v1
article 2025
Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration
·doi:10.1002/adhm.202501767

The extracellular matrix (ECM) constantly remodels to tailor a temporal spatial specific environment for the residing cells to respond to physiological or pathological stimuli. Endometrial mesenchymal stem cells (eMSC) are excellent therape…

article 2024
Interleukin 6 at menstruation promotes the proliferation and self-renewal of endometrial mesenchymal stromal/stem cells through the WNT/β-catenin signaling pathway
·doi:10.3389/fimmu.2024.1378863

Background: eMSC) located in the basalis are responsible for the cyclical regeneration of the endometrium after menstruation. Endometrial cells from the menstruation phase have been proven to secrete a higher amount of IL-6 and further enha…

article 2023
A construct of adipose-derived mesenchymal stem cells—laden collagen scaffold for fertility restoration by inhibiting fibrosis in a rat model of endometrial injury
·doi:10.1093/rb/rbad080

Abstract Severe endometrium damage causes pathological conditions such as thin endometrium and intrauterine adhesion, resulting in uterine factor infertility. Mesenchymal stem cell (MSC) therapy is a promising strategy in endometrial repair…

preprint 2022
The Role of Notch Signaling in Endometrial Mesenchymal Stromal/Stem-like Cells Maintenance
·doi:10.1101/2022.02.09.479815

Abstract Human endometrium undergoes cycles of regeneration in reproductive women. The endometrial mesenchymal stromal/stem cells (eMSC) contribute to this process. Notch signaling is essential for the homeostasis of somatic stem cells. How…

article 2020
Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation
·doi:10.1186/s13287-020-01750-3

BACKGROUND: The identification of endometrial stem/progenitor cells in a high turnover rate tissue suggests that a well-orchestrated underlying network controls the behaviour of these stem cells. The thickness of the endometrium can grow fr…

article 2017
Co‐culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells
Cell proliferation ·doi:10.1111/cpr.12330

OBJECTIVE: To study the effect on endometrial and endometriotic cells after co-culture with macrophages, using clonogenic, invasion and self-renewal assays. MATERIALS AND METHODS: Peripheral blood samples, endometrium and endometriotic tiss…

article 2016
Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle
·doi:10.1016/j.yexcr.2016.11.020
article 2012
Human Female Reproductive Tract Epithelial Cell Culture
Methods in molecular biology (Clifton, N.J.) ·doi:10.1007/978-1-62703-125-7_21

The female reproductive system is a complex system. Epithelia of the female reproductive system including the ovaries, the oviduct, and the uterus are important sites for follicular development, ovulation, fertilization, implantation, and e…

article 2011
Identification of Cells with Colony-Forming Activity, Self-Renewal Capacity, and Multipotency in Ovarian Endometriosis
The American journal of pathology ·doi:10.1016/j.ajpath.2011.02.025
article 2010
Upregulation of Endocrine Gland-Derived Vascular Endothelial Growth Factor, But Not Vascular Endothelial Growth Factor in Human Ectopic Endometriotic Tissue
·doi:10.1097/ogx.0b013e3181f07bc1

Previous studies have shown that the expression of vascular endothelial growth factor (VEGF) is critical for the development and growth of transplanted endometriosis-like lesions in mouse model systems. The angiogenic response induced by an…

article 2009
Up-regulation of endocrine gland-derived vascular endothelial growth factor but not vascular endothelial growth factor in human ectopic endometriotic tissue
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.12.001
review 2007
The role of endometrial blood flow measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during in vitro fertilization treatment
·doi:10.1016/j.ejogrb.2007.06.006
article 1998
The effects of follicular fluid from patients with different indications for IVF treatment on the binding of human spermatozoa to the zona pellucida
Human Reproduction ·doi:10.1093/humrep/13.1.128

This study compared the effects of human follicular fluid (hFF) from women with endometriosis, tubal factor and male factor on the zona binding capacity of human spermatozoa. Samples of hFF were collected from 30 patients, 10 patients for e…

article 1992
Intrauterine insemination after ovarian stimulation as a treatment for subfertility because of subnormal semen: a prospective randomized controlled trial
·doi:10.1016/s0015-0282(16)55449-1