Intrauterine insemination after ovarian stimulation as a treatment for subfertility because of subnormal semen: a prospective randomized controlled trial
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This randomized controlled trial investigated the effectiveness of intrauterine insemination following ovarian stimulation as a treatment for subfertility attributed to subnormal semen quality.
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Abstract
ObjectiveTo determine whether intrauterine insemination (IUI) after ovarian stimulation with human menopausal gonadotropin (hMG) gives a better pregnancy rate (PR) than natural intercourse in couples with subfertility because of subnormal semen.DesignProspective randomized controlled trial.SettingUniversity based subfertility clinic.PatientsCouples with subnormal semen as the only identifiable cause of subfertility.InterventionsIn control cycles, the couples had natural intercourse. In IUI cycles, IUI was performed after ovarian stimulation with hMG and human chorionic gonadotropin.Main outcome measureThe clinical PRs and complications of IUI cycles and control cycles were compared.ResultsThere were six clinical pregnancies in the 42 IUI cycles, whereas there was no clinical pregnancy in the 42 control cycles. The clinical PR in IUI cycles (14.3% per cycle) was significantly higher than that in control cycles (0%). Six patients (14.3%) developed moderate degree of ovarian hyperstimulation syndrome in IUI cycles.ConclusionIntrauterine insemination after ovarian stimulation with hMG is useful in treatment of subfertile couples with subnormal semen.
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Cited by (3)
- Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility: Should the guidelines be changed? 2003
- Experience with transvaginal ultrasound-guided aspiration of supernumerary follicles for the prevention of multiple pregnancies after ovulation induction and intrauterine insemination 1996
- Intrauterine insemination (IUI) treatment in subfertility 1999
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Cited by (3)
- Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility: Should the guidelines be changed? 2003
- Intrauterine insemination (IUI) treatment in subfertility 1999
- Experience with transvaginal ultrasound-guided aspiration of supernumerary follicles for the prevention of multiple pregnancies after ovulation induction and intrauterine insemination 1996
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