Izumi Kusuki

No ORCID on file · 42 papers in corpus · active 1999-2025

Study types

  • article 35
  • other 4
  • case-report 2
  • review 1

Condition tags

  • endometriosis 41
  • endometrioma 8
  • adenomyosis 5
  • chronic_pelvic_pain 2
  • infertility 2
  • die_deep_infiltrating 2
  • bladder_endometriosis 1
  • dyspareunia 1
  • dysmenorrhea 1
article 2015
G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.01.026

ObjectiveTo demonstrate the effects of the selective G protein-coupled estrogen receptor 1 (GPER) agonist G-1 in human ovarian endometriotic stromal cells (ESCs).DesignExperimental in vitro study.SettingUniversity hospital.Patient(s)A total…

other 2014
(18)F-fluorodeoxyglucose positron emission tomography/computed tomography-positive lymph node endometriosis masquerading as lymph node metastasis of a malignant tumor
Case reports in obstetrics and gynecology ·doi:10.1155/2014/648485

Endometriosis is defined as the presence of endometrium-like tissues at extrauterine sites, most commonly in the abdominal cavity. Lymph node endometriosis is a rare but clinically important type of endometriosis that can mimic lymph node m…

article 2014
Clear Cell Carcinoma Arising from Cesarean Section Scar Endometriosis: Case Report and Review of the Literature
Case reports in obstetrics and gynecology ·doi:10.1155/2014/642483

Introduction. The incidence of endometriosis affecting skin tissue represents only 0.5-1.0% of all endometriosis cases. A malignancy in the abdominal wall arising from endometriosis following cesarean section is even rarer; only 21 cases ha…

article 2014
ISAC-4-3 Stimulation of Aromatase by Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 Alpha (PGC-1α) in Endometriosis(Group 4 Reproduction,IS Award Candidate,International Session)
article 2014
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2013-2525

CONTEXT: Endometriosis is an estrogen-dependent disease, and estrogen is overproduced by abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated receptor gamma, coactivator 1α (PGC-1α) is a transcriptional …

article 2012
Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2012.08.023

ObjectivesLow-dose estrogen-progestin (LEP) agents are often used for relieving endometriosis-associated chronic pelvic pain, but a direct effect of LEP on endometriotic lesions remains to be demonstrated. The objective of this study is to …

article 2012
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.11.005

ObjectiveTo determine the effect of dienogest (DNG) on the expression of aromatase and cyclooxygenase-2 (COX-2) and the production of prostaglandin E(2) (PGE(2)) in human endometriotic stromal cells (ESCs).DesignExperimental study in vitro.…

article 2011
Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2011.03.012

ObjectiveTo examine whether long-term administration of dienogest following gonadotropin-releasing hormone agonist (GnRH-a) therapy would prolong the relief of pelvic pain while reducing the amount of irregular uterine bleeding.Study design…

article 2010
IS-20 Frequent loss of heterozygosity in ovarian cancer arising from endometriosis : possible involvement in malignant transformation(Group2 Oncology2,International Session) :
article 2010
Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis
Gynecologic oncology ·doi:10.1016/j.ygyno.2010.10.036

ObjectiveAlthough histological and epidemiological studies have suggested that endometriosis has malignant potential, the molecular mechanism underlying the malignant transformation of endometriosis is poorly understood. Ovarian cancer aris…

article 2002
Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women
Human Reproduction ·doi:10.1093/humrep/17.4.897

BACKGROUND: To investigate whether polymorphisms of CYP17 and CYP19 genes are associated with the risk of endometriosis, we analysed the frequency and distribution of a single nucleotide polymorphism at the 5' untranslated region of the CYP…

other 2002
Genetic contribution of the interleukin-10 promoter polymorphism in endometriosis susceptibility
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1034/j.1600-0897.2002.1o029.x

PROBLEM: Interleukin-10 (IL-10) is an important immunomodulatory cytokine. The aim of this study was to investigate whether polymorphisms of the IL-10 gene promoter polymorphisms may be responsible in part for genetic susceptibility to endo…

article 2001
[Hormone responsiveness of endometriosis].
Nihon rinsho. Japanese journal of clinical medicine
article 2001
Immunohistochemical localization of aromatase and apoptosis-associated proteins in ovarian serous cystadenocarcinoma arising from ovarian endometriosis
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/s0301-2115(01)00288-3

An immunohistochemical study was made of a case of serous cystadenocarcinoma that had been shown to have arisen from ovarian endometriosis. Aromatase cytochrome P450 (P450arom), an enzyme responsible for estrogen biosynthesis, was localized…

article 2000
Progesterone Induction of 17β-Hydroxysteroid Dehydrogenase Type 2 during the Secretory Phase Occurs in the Endometrium of Estrogen-Dependent Benign Diseases But Not in Normal Endometrium
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.85.9.6829

In the human endometrium, inactivation of 17beta-estradiol to estrone is catalyzed by 17beta-hydroxysteroid dehydrogenase type 2 (17betaHSD2). Previous studies have shown that the 17betaHSD2 activity in the endometrium is elevated during th…

article 1999
Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(99)00424-0

ObjectiveTo evaluate the clinical usefulness of examining endometrial biopsy specimens for aromatase cytochrome P-450 as a diagnostic test for endometriosis.DesignRetrospective, case-controlled study.SettingDepartment of Obstetrics and Gyne…

review 1999
Expression of Aromatase Cytochrome P450 in Eutopic Endometrium and Its Application as a Diagnostic Test for Endometriosis
Gynecologic and obstetric investigation ·doi:10.1159/000052865

Endometriotic implants, like other estrogen-dependent tumors, contain both estrogen receptors and aromatase cytochrome P450 (P450arom), suggesting that at a local level, endometriotic implants produce estrogens, which may be involved in tis…