Grant W Montgomery

BACKGROUND: Endometriosis affects 11% of women of reproductive age. Diagnosis is often delayed by 6-8 years due to nonspecific symptoms and lack of early detection tools. This study aimed to develop an early risk prediction model for endome…

Abstract Progestins are important first line and adjuvant medications for endometriosis, yet their efficacy varies among patients. Dienogest (DNG), a 4th generation progestin, is one of the most prescribed and successful progestins, althou…

Human endometrium sheds and regenerates each month during the menstrual cycle. N-cadherin+ (CDH2) glandular epithelial progenitors and SUSD2+ mesenchymal stem cells (MSCs) and their niches have been identified, but their signaling interacti…

The human endometrium is a complex, dynamic, and poorly understood tissue involving monthly cyclical regeneration likely from adult stem/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis …

Abstract Background Human endometrium is a complex tissue lining the inside of the uterus and is essential for female fertility. It comprises several cell types, including endometrial stromal and epithelial cells, whose structure and functi…

BACKGROUND: Women with endometriosis have more hospitalisations compared to those without the condition. However, no longitudinal study has examined hospital admission rates and lengths of stay before and after diagnosis. We examined all-ca…

Endometriosis is a complex disease, and many genetic and environmental risk factors contribute to disease risk. The genetic risk of endometriosis has been well characterized in genome-wide association studies. While few physiological risk f…

Endometriosis is a common gynecologic condition that causes chronic, life-altering symptoms including pain and infertility. There is an urgent need for new non-hormonal targeted therapeutics to treat endometriosis, but until very recently, …

Endometriosis is a chronic gynaecological disease characterised by endometrial-like tissue found external to the uterus. While several studies have reported strong evidence of a genetic contribution to the disease, studies on the environmen…

STUDY QUESTION: What are the patterns of health service use (HSU) before and after endometriosis diagnosis? SUMMARY ANSWER: Women with endometriosis had higher rates of visits to general practitioners (GPs), specialists, and diagnostic ima…

The endometrium, essential for reproduction, undergoes cyclical shedding, remodeling, and regeneration. Using a large endometrial transcriptomic dataset (n = 206), we identified RNA splicing and transcript isoform-level changes across the m…

BACKGROUND: Endocannabinoids are small lipid molecules that have critical roles in cellular proliferation and function. They are produced locally with their concentrations controlled via the endocannabinoid system (ECS). The important cellu…

OBJECTIVES: To assess the validity and reliability of self-reported diagnoses of endometriosis. STUDY DESIGN: The study included 8572 women from two Australian birth cohorts (1989-95 and 1973-78), using data from the Genetic variants, Earl…

Introduction: Anandamide (AEA) and 2-arachidonoylglycerol are endogenous agonists of the cannabinoid receptors and regulate and control many cellular functions. Their activities are governed by enzymes and proteins that regulate their synth…

Study questionWhich genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins?Summary answerWe identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and…

Endometriosis is a common gynecologic condition that causes chronic life-altering symptoms including pain, infertility, and elevated cancer risk. There is an urgent need for new non-hormonal targeted therapeutics to treat endometriosis, but…

BACKGROUND: Despite surgical and pharmacological interventions, endometriosis can recur. Reliable information regarding risk of recurrence following a first diagnosis is scant. The aim of this study was to examine clinical and survey data i…

BACKGROUND: Endometriosis may be linked to the risk of iron deficiency through chronic systemic inflammation or heavy menstrual bleeding. No longitudinal studies, however, have examined the relationship between endometriosis and the risk of…

Additional file 1: Table S1. Statin Adjustment Factors and Linear Regression Analysis of Effect of Statin Usage on Biomarker Levels. Table S2. PRS-PheWAS of phecodes in females utilising endometriosis PRS. Table S3. PheWAS of phecodes in fe…

Additional file 1: Table S1. Statin Adjustment Factors and Linear Regression Analysis of Effect of Statin Usage on Biomarker Levels. Table S2. PRS-PheWAS of phecodes in females utilising endometriosis PRS. Table S3. PheWAS of phecodes in fe…

Abstract Endometriosis is one of the most common chronic gynaecological disorders. Historically, public and professional awareness of the disorder and its consequences has been poor; however, in recent times, there has been greater recognit…

Natural variability in menstrual cycle length, coupled with rapid changes in endometrial gene expression, makes it difficult to accurately define and compare different stages of the endometrial cycle. Here we develop and validate a method f…