Endometrial Cell-Type Specific Regulation of the Endocannabinoids System and the Impact of Menstrual Cycle and Endometriosis

Keisuke Tanaka, Sugarniya Subramaniam, Sharat Atluri, Akwasi Amoako, Akwasi A Amoako, Sally Mortlock, Grant W Montgomery, Brett McKinnon
Cannabis and cannabinoid research · 2024 · vol. 10(4) , pp. 512–526 · doi:10.1089/can.2024.0081 · PMID:39286880 · W4402575849
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This study investigated the regulation of the endocannabinoid system in human endometrial cells by examining RNA and protein expression across the menstrual cycle and in the context of endometriosis.

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Abstract

Introduction: Anandamide (AEA) and 2-arachidonoylglycerol are endogenous agonists of the cannabinoid receptors and regulate and control many cellular functions. Their activities are governed by enzymes and proteins that regulate their synthesis, receptor binding, transport, and degradation, which are known as the endocannabinoid system (ECS). The aim of this study was to investigate the regulation of endocannabinoid activity in the endometrium by studying the RNA and protein expression of the ECS within endometrial cell types and during different menstrual cycle stages and the impact of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids Endocannabinoids

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (39)

SciLite annotations

chemicals 6
endocannabinoid anandamide 2-arachidonoylglycerol endocannabinoid endocannabinoid endocannabinoid

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