Maharani Maharani

Context: Endometriosis is a chronic estrogen-dependent inflammatory disorder associated with pelvic pain and infertility. Flavonoids from Phaleria macrocarpa have been reported to exhibit anti-inflammatory activity; however, their molecular…

Endometriosis is a complex and multifactorial disease causing severe pelvic pain, infertility, and reduced quality of life in women. Therefore, this study aimed to evaluate the preventive potential of Phaleria macrocarpa (PM) mesocarp ethan…

Context: Endometriosis is the presence of endometrial glands and stromal lesions outside the uterus. Aims: To investigate the network pharmacology and molecular docking of Phaleria macrocarpa bioactive compounds on selected endometriosis pa…

Endometriosis is a complex and multifactorial disease causing severe pelvic pain, infertility, and reduced quality of life in women. Therefore, this study aimed to evaluate the preventive potential of Phaleria macrocarpa (PM) mesocarp ethan…

Endometriosis (EM) is a gynecological disorder that causes morbidity in women and is characterized by endometrial tissue in the uterus cavity. This study investigated the mechanism of genistein in the VEGF-A and ER-α expression through in v…

Context: Endometriosis is a condition marked by the presence of endometrial epithelium and stromal cells outside the uterus. Previous studies have shown that prostaglandin E2 has a role in the development of endometriosis via the action of …

Introduction: Endometriosis is a medical condition in which there is abnormal growth of tissue resembling the endometrium outside the uterus. It can cause symptoms of pain and/or infertility. The current medical therapy focuses on reducing …

Around 5—10% women in their productive age could suffer from endometriosis, a condition where viable endometrial tissue is present outside the uterine cavity. This disease could progress into ovarian cancer and infertility with long-lasting…

Endometriosis is a inflamatory disease especially in the state of reproductive age. Phaleria macrocarpa is a plant that has a population in Papua, Irian Jaya. Endometriosis therapies available have still many weakness, including being expen…

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Introduction: Endometriosis is a gynaecological disorder in women and causes infertility. Several therapeutic were developed to reduce endometriosis cases, one of them was matrix metalloproteinase (MMP) inhibitor. This study investigated th…

Latar Belakang: Matrix metalloproteinases (MMPs) mempengaruhi progesivitas endometriosis, dalam invasi, perkembangan dan metastasis endometriosis. Penururan kadar MMP-2 dan MMP-9 merupakan terapi yang tepat untuk kasus endometriosis menggun…

Background: Endometriosis is one of the main reproductive problems today because the incidence is quite high. The development and progression of endometriosis cells results from an abnormal balance between cell proliferation and apoptosis. …

BACKGROUND: Endometriois represents a gynecological disease that still becomes an issue in community. Phaleria macrocarpa is a plant native to Indonesia that contains an antioxidant substance, which may serve as apoptotic modulator and usef…

INTRODUCTION: to inhibit the development of inflammation in endometriosis. AIM: way. MATERIAL AND METHODS: analyzed here were including aviculin (CID 10391477), caffeine (CID 2519), catechin (CID: 9064), epicatechin (CID: 72276), kaempferol…

This in silico and in vivo investigation were to know the effect of genistein on alteration of MMPs in a mice model of endometriosis. Forty female mice (Mus musculus) were divided into eight groups (n=5 each), including the control (untreat…