Guan L
ORCID: 0000-0002-5090-7140
· 21 papers in corpus
observational
2026
BACKGROUND: This study evaluated the effects of different ovulation trigger strategies on pregnancy outcomes in letrozole-stimulated and modified natural frozen–thawed embryo transfer (L-FET and mNC-FET) cycles. METHODS: A total of 2053 eli…
lab-animal
2026
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by chronic low-grade inflammation of the ovaries. This disorder of the immune microenvironment is closely related to abnormal follicular development and ovulation disorders. This…
lab-animal
2026
BACKGROUND: Diminished ovarian reserve (DOR) is associated with impaired female fertility; however, its molecular mechanisms remain incompletely understood. Our previous studies found that individuals with DOR have lower levels of microRNA-…
other
2025
PURPOSE: To investigate BMAL1 and BMP6 expressive differences in ovarian granulosa cells (OGCs) of patients with polycystic ovary syndrome (PCOS), explore regulatory relationship, assess their impacts on OGC proliferation and apoptosis, and…
observational
2025
OBJECTIVE: This study aimed to analyze the effect of progesterone (P) levels on the human chorionic gonadotropin (hCG) trigger day and the progesterone on hCG day-to-basal progesterone (PhCG/Pbasal) ratio on pregnancy outcomes in patients w…
other
2025
BACKGROUND: Female reproductive disorders (FRDs) are common diseases among women of childbearing age, affecting their reproductive health. Age at first sexual intercourse (AFS) is potentially linked to FRDs, and this study aims to investiga…
rct
2024
BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous gynecological endocrine disorder linked to immunity. Cangfu Daotan Decoction (CFDT), a classic Chinese medicine prescription, is particularly effective in treating PCOS, specif…
observational
2023
The aim of this study is to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement regimen for frozen-thawed embryos. We performed a retrospective cohort study and included patients who underwent frozen embryo t…
rct
2022
To investigate the clinical value of Mirena (levonorgestrel intrauterine sustained release system) combined with gonadotropin-releasing hormone agonist (GnRH-a) in patients with endometriosis, 80 patients with endometriosis (March 2019 ~ Ma…
other
2022
Research hotspots and trends in visceral pain research: A global comprehensive bibliometric analysis
BACKGROUND: Visceral pain is a complex and heterogeneous disorder that is considered more prominent compared to somatic pain, due to its multiple and complex causes and accompanying emotional and mood disorders. Research has become increasi…
observational
2022
BACKGROUND: Previous studies have shown that frozen embryo transfer (FET) resulted in increased live birth rates (LBR) and reduced the risk of ovarian hyperstimulation syndrome (OHSS) than did fresh embryo transfer in women with polycystic …
meta-analysis
2020
BACKGROUND: Asthma and diabetes are both diseases that affect a wide range of people worldwide. As a common treatment for diabetes, metformin has also been reported to be effective in improving asthma outcomes. We conducted a combined analy…
observational
2019
Background: Oxidative stress plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). Glutathione peroxidase 1 (GPx1) and catalase (CAT) are the major intracellular antioxidant enzymes that can detoxify hydrogen pero…
other
2019
The authors regret that the incorrect identification of "omega-3 arachidonic acid" published in the original manuscript [1].
lab-animal
2018
BACKGROUND/AIMS: Menstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in tissues and the …
observational
2018
This retrospective analysis aimed to clarify the clinical and pathologic features of ovarian clear cell carcinoma (OCCC), and to determine the factors predictive of survival.Data waereextracted from OCCC patients who underwent primary surge…
other
2018
The sensitivity and specificity of clinical diagnostic indicators and non-invasive diagnostic methods for endometriosis at early stage is not optimal. Previous studies demonstrated that abnormal lipid metabolism was involved in the patholog…
observational
2018
BACKGROUND: Elevated serum levels of apolipoprotein (apo) C1 may be an early protein marker of metabolic abnormality in women with polycystic ovary syndrome (PCOS). It is not clear, however, whether there are any relationships between the a…
observational
2018
BACKGROUND: Considered as the precursor lesion of a subset of ovarian clear cell carcinoma (OCCC), the prognostic role of endometriosis in OCCC patients remains controversial. This study aimed to investigate the prognostic role of coexistin…
diagnostic-accuracy
2018
BACKGROUND: The sensitivity and specificity of non-invasive diagnostic methods for endometriosis, especially at early stages, are not optimal. The clinical diagnostic indicator cancer antigen 125 (CA125) performs poorly in the diagnosis of …
observational
2017
BACKGROUND: The G994T polymorphism in platelet-activating factor acetylhydrolase (PAF-AH) gene is associated with the risk of polycystic ovary syndrome (PCOS). The aim of this study was to investigate the relationship between R92H and A379V…