Correction to: Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages

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This correction identifies an error in the original manuscript regarding the identification of "omega-3 arachidonic acid" in endometrium metabolomic profiling for endometriosis biomarkers.

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This paper is a correction notice to a previously published study on endometrial metabolomic profiling for diagnostic biomarkers in endometriosis at minimal-to-mild stages. The authors report that “omega-3 arachidonic acid” was incorrectly identified in multiple locations, and after rechecking the metabolite fragmentation spectra and comparing m/z values with the Metlin database, they conclude the correct metabolite is arachidonic acid (an omega-6 polyunsaturated fatty acid). They note the misclassification could matter mechanistically because arachidonic acid is hypothesized to play a role in inflammatory processes, and they specify exactly where in the abstract, introduction, results, discussion, and figures/tables the wording should be corrected. This paper is centrally about endometriosis — it corrects metabolite labeling in an article focused on endometriosis diagnosis using endometrium metabolomic biomarkers at minimal-mild stages.

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Abstract

The authors regret that the incorrect identification of "omega-3 arachidonic acid" published in the original manuscript [1].
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Abstract

and text, a correction is warranted. Accordingly, the name “omega-3 arachidonic acid ” mentioned in the following parts should be corrected as “arachidonic acid ”: /C15In the results section of Abstract: “The eutopic endometrium metabolomic profile of the endometriosis patients was characterized by a significant increase in the concentration of hypoxanthine, L-arginine, L-tyrosine, leucine, ly- sine, inosine, omega-3 arachidonic acid, guanosine……”. /C15In the last paragraph of Introduction: “The eutopic endometrium metabolomic profile of endometriosis patients was characterized by a significant increase in the concentration of hypoxanthine, L-arginine, L-tyrosine, leucine, lysine, inosine, omega-3 arachidonic acid, guanosine……”. /C15In the first paragraph of the section with the subheading “Identification of detected metabolites ” of Results: “Obviously, levels of hypoxanthine, L- arginine, L-tyrosine, leucine, lysine, inosine, omega-3 arachidonic acid, guanosine …..” /C15In the first paragraph of Discussion: “In this regard, 11 metabolites including hypoxanthine, L-arginine, L-tyrosine, leucine, lysine, inosine, omega-3 arachi- donic acid, guanosine ……” /C15Figure 2D, “Omega-3 Arachidonic acid ” /C15In the third row of Figure 3, “omega-3 arachidonic acid” /C15In the third graph in the first row of Figure 4, “Omega-3 Arachidonic acid ” /C15In the 4th row of RPLC mode in Table 2, “Omega-3 Arachidonic acid ” The authors would like to apologize for any inconvenience caused. © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. * Correspondence: [email protected] The original article can be found online at https://doi.org/10.1186/s12958- 018-0360-z †Jingjie Li and Lihuan Guan contributed equally to this work. 2School of Pharmaceutical Sciences in Sun Yat-sen University, 132# Waihuandong Road, Guangzhou, University City, Guangzhou 510006, People’s Republic of China Full list of author information is available at the end of the article Li et al. Reproductive Biology and Endocrinology (2019) 17:89 https://doi.org/10.1186/s12958-019-0532-5 Author details 1Center of Reproductive Medicine, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 2School of Pharmaceutical Sciences in Sun Yat-sen University, 132# Waihuandong Road, Guangzhou, University City, Guangzhou 510006, People ’s Republic of China. 3Pharmacy Department, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 4School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Reference

1. Li J, et al. Endometrium metabolomic profiling reveals potential biomarkers for diagnosis of endometriosis at minimal-mild stages. Reprod Biol Endocrinol. 2018;16:42. https://doi.org/10.1186/s12958-018-0360-z. Li et al. Reproductive Biology and Endocrinology (2019) 17:89 Page 2 of 2

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