Anne Van Langendonckt

ObjectiveTo identify metabolites that are associated with and predict the presence of endometriosis.DesignMetabolomics study using state-of-the-art mass spectrometry approaches.SettingUniversity hospital and universities.Patient(s)Twenty-fi…

BACKGROUND: In animal models of endometriosis, the identification and quantification of lesions originating from human endometrium is often hampered by the small size of the implants and their embedding in murine tissue. The purpose of the …

ObjectiveTo evaluate, in peritoneal, ovarian, and rectovaginal endometriotic lesions, expression of steroidogenic enzymes involved in the activation and inactivation of estrogens: 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) and 2 (HSD…

ObjectiveTo study the occurrence of nerve fibers in deep nodular endometriotic lesions after nodules were induced in baboons and nerve fiber densities measured 6 months after the grafting procedure.DesignExperimental animal study.SettingAca…

Objective Detection of nerve fibers in endometrial biopsies was recently proposed as a noninvasive diagnostic tool for endometriosis. However, their occurrence in the functional layer of endometrium still remains controversial. Nerve fibers…

ObjectiveTo establish an experimental model for the study of deep nodular endometriosis.DesignInduction of nodular endometriosis in baboons by grafting different uterine specimens to the peritoneal cavity.SettingResearch and university faci…

ObjectiveTo evaluate the adverse effects of endometriomas on ovarian reserve.DesignAnalysis of prospectively collected biopsy samples.SettingGynecology research unit in a university hospital.Patient(s)Women younger than age 35 years with en…

BACKGROUND: Steroid sulfatase (STS) is involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of disease-free and endometriosis patients. The present study was designed to investigate its role in endometriosis de…

Endometriosis is an estrogen-dependent disorder. Treatment with hormonal therapy suppresses estrogen and leads to regression of lesions. However, hormonal therapy is associated with significant morbidity, adverse effects, and recurrence of …

Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometri…

ObjectiveTo determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons.DesignInduction and follow-up of endometriosis in baboons, which is one of the primate …

Peritoneal endometriosis is a chronic inflammatory disease characterized by increased numbers of peritoneal macrophages and their secreted products. Inflammation plays a major role in pain and infertility associated with endometriosis, but …

In this study, we developed an original and reproducible quantitative in vitro model of endometrial cell adhesion to peritoneal mesothelial cells in order to better assess the impact of pro-inflammatory cytokines on early-stage endometriosi…

ObjectiveTo compare expression of homeobox A (HOXA) genes involved in the differentiation of the female reproductive tract in deep endometriotic nodules and peritoneal lesions.DesignProspective experimental study.SettingAcademic gynecology …

ObjectiveTo evaluate the role of nuclear factor-κB (NF-κB) in the pathogenesis of endometriosis.DesignA literature search was conducted in PubMed to identify all relevant citations.Result(s)Our findings highlight the important role of NF-κB…

BACKGROUND: Aromatase has been reported to be involved in estrogen biosynthesis and expressed in eutopic and ectopic endometrium of endometriosis patients. The objective of the present study was to investigate its expression and localizatio…

BACKGROUND/AIMS: Endometriosis is known to be an estrogen-dependent disease. However, only a few studies have analyzed the effect of estrogen treatment in mice xenotransplanted with human endometrium. The objective of this study was to adap…

BACKGROUND: Increased peritoneal eicosanoid concentrations have been reported in endometriosis patients and might be important in disease-associated pain and inflammation. Here, we evaluated the expression of key biosynthetic and catabolic …

PurposeEctopic endometrial tissue is biochemically and functionally distinct from eutopic endometrium, including differences in receptivity to steroids and invasive potential. For this reason, using ectopic endometrial tissue to induce endo…

Purpose Ectopic endometrial tissue is biochemically and functionally distinct from eutopic endometrium, including differences in receptivity to steroids and invasive potential. For this reason, using ectopic endometrial tissue to induce end…

Peritoneal endometriosis is a chronic pelvic inflammatory disease, characterized by increased numbers of peritoneal macrophages and their secreted products such as cytokines, growth and angiogenic factors in peritoneal fluid. Inflammation p…

Peritoneal endometriosis is a chronic pelvic inflammatory disease, characterized by increased numbers of peritoneal macrophages and their secreted products such as cytokines, growth and angiogenic factors in peritoneal fluid. Inflammation p…

Classic murine endometriosis models may be insufficient to evaluate the effect of therapeutic agents on endometriosis development, because the process of identification and measurement of induced lesions is often impeded, as implants are sm…