Bruce A Lessey

No ORCID on file · 197 papers in corpus · active 1989-2026

Study types

  • article 140
  • other 24
  • review 18
  • letter 5
  • preprint 5

Condition tags

  • endometriosis 176
  • infertility 64
  • chronic_pelvic_pain 13
  • dysmenorrhea 5
  • die_deep_infiltrating 4
  • endometrioma 3
  • dyspareunia 2
  • adenomyosis 2
  • irritable_bowel_syndrome 1
  • interstitial_cystitis 1
article 2016
·doi:10.5256/f1000research.8083.r12518
article 2016

AT-rich interactive domain 1A gene (ARID1A) loss is a frequent event in endometriosis-associated ovarian carcinomas. Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus, and 50 % of wome…

other 2016
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.11.047

OBJECTIVE: To determine the impact of endometriotic lesion removal on local and systemic inflammation. DESIGN: Multiplex cytokine analysis on samples from endometriosis patients before surgery, 2 weeks after surgery, and 3 months after sur…

article 2016
·doi:10.1016/j.fertnstert.2016.07.274
article 2016
·doi:10.1016/j.fertnstert.2016.07.774
article 2015
Human Reproduction ·doi:10.1093/humrep/dev050

STUDY QUESTION: Are STAT3 signaling molecules differentially expressed in endometriosis? SUMMARY ANSWER: Levels of phospho-STAT3 and HIF1A, its downstream signaling molecule, are significantly higher in eutopic endometrium from women with e…

other 2015
PLoS genetics ·doi:10.1371/journal.pgen.1005537

AT-rich interactive domain 1A gene (ARID1A) loss is a frequent event in endometriosis-associated ovarian carcinomas. Endometriosis is a disease in which tissue that normally grows inside the uterus grows outside the uterus, and 50% of women…

other 2015
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719114542011

C-X-C ligand 13 (CXCL13), a regulator of mucosal immunity, is secreted by human endometrial epithelium and may be involved in embryo implantation. However, cyclic expression of human endometrial CXCL13 in health and disease is not well stud…

article 2015
·doi:10.1016/j.fertnstert.2015.07.257
article 2015
·doi:10.1016/j.fertnstert.2015.07.022
article 2015
Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.1501138

Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endo…

article 2014
·doi:10.1016/j.fertnstert.2014.07.043
article 2014
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12259

PROBLEM: Uterine natural killer cells (uNK) have been thought to play a key role in endometriosis and infertility. We investigated the expression of CD56, CD16, and NKp46 in endometrial tissues from 61 women with unexplained recurrent pregn…

article 2014
·doi:10.5301/je.5000181

Purpose The aim of this study was to investigate if there is a higher incidence of endometriosis in patients with polycystic ovary syndrome (PCOS), compared with normal fertile controls. Material and methods Women with PCOS according to Rot…

other 2014
PloS one ·doi:10.1371/journal.pone.0100481

Endometriosis, defined as the presence of endometrial cells outside of the uterine cavity, is a major cause of infertility and pelvic pain, afflicting more than 10% of reproductive age women. Endometriosis is a chronic inflammatory disease …

article 2014
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-3720

CONTEXT: Endometriosis is a common gynecological disease affecting one in 10 women of reproductive age and is a major cause of pelvic pain and impaired fertility. Endometrial stromal cells of women with endometriosis exhibit a reduced respo…

article 2014
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719114553064

Endometriosis affects up to 10% of women of reproductive age and 176 million women worldwide. The prevalence in women with infertility is between 30% and 50% but may be higher in women with pelvic pain, interstitial cystitis, or irritable b…

article 2014
·doi:10.5301/je.5000191

Aims The aim of this study was to identify whether endometriosis is a progressive disease with age, and to review the literature on this topic. Material and methods The incidence of endometriosis in a cohort of 500 women who underwent lapar…

article 2014
Human Reproduction ·doi:10.1093/humrep/deu146

STUDY QUESTION: Are the transmembrane mucins, MUC1, MUC4 and MUC16, differentially expressed in endometriosis compared with normal endometrium? SUMMARY ANSWER: This study revealed that transmembrane mucin expression does not vary significan…

review 2014
Seminars in reproductive medicine ·doi:10.1055/s-0034-1376355

Embryo implantation is regulated by an inflammatory process in response to sequential exposure to estrogen and progesterone, followed by resolution and repair. The actions of estrogen and progesterone on these inflammatory processes are tig…

article 2014
·doi:10.1096/fasebj.28.1_supplement.539.2

Cytokines present within the environment of endometriosis are believed to contribute to the pathogenesis of the disease by promoting inflammatory conditions surrounding the implantation of endometriotic lesions. Interleukin‐17A is a member …

other 2014
Fertility and sterility ·doi:10.1016/j.fertnstert.2014.02.027

OBJECTIVE: To evaluate endometrial leukemia inhibitor factor (LIF) expression as a marker of endometrial receptivity in women with unexplained infertility (UI). DESIGN: Prospective case-control study. SETTING: University-associated infert…

article 2014
·doi:10.1016/j.fertnstert.2014.07.1012
article 2014
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719114525271

Resveratrol is a natural phytoestrogen with antiproliferative properties present in red wine, grapes, and berries. Published reports on the effects of resveratrol in human endometrial function are limited. The objective of this study was to…

review 2014
Biology of reproduction ·doi:10.1095/biolreprod.114.125021

The p160/steroid receptor coactivator (SRC) family comprises three pleiotropic coregulators (SRC-1, SRC-2, and SRC-3; otherwise known as NCOA1, NCOA2, and NCOA3, respectively), which modulate a wide spectrum of physiological responses and c…