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- endometriosis 8
- infertility 3
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BACKGROUND: Endometriosis is a benign gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus. Proliferation of endometrial tissue and neoangiogenesis are essential factors in the development of e…
BACKGROUND: Endometrioma, a common manifestation of endometriosis, often indicates the severity of the disease. In vitro fertilization and embryo transfer (ET) are key therapeutic strategies for infertility associated with endometriosis. Ho…
BACKGROUND: Fertility preservation is an important aspect of care for breast cancer patients. This study was designed to compare the ovarian function including ovarian reserve and ovarian stimulation response in breast cancer patients under…
BACKGROUND: genes and HOX transcript antisense intergenic RNA (HOTAIR) in mid-luteal phase endometrium in patients with hydrosalpinx before and after salpingectomy. MATERIALS AND METHODS: . RESULTS: mRNA expression levels (P=0.012) were det…
BackgroundEctopic pregnancy (EP) is defined as embryo implantation in a location other than the uterine cavity.ObjectiveWe aimed to evaluate the expression of several genes, which may play a role in EP, in the ampulla region of fallopian tu…
Today, timely diagnosis and therapeutic progress open a road of hope for survival in cancerous patients. Increased knowledge about the various cytotoxic treatment's impacts on ovarian function and fertility has resulted in a surge in the nu…
BackgroundEctopic pregnancy (EP) is defined as implantation and development of an embryo outside of the uterine tissue. Women undergoing assisted reproductive technologies (ART), particularly frozen embryo transfer (FET), are in high-risk p…
BACKGROUND: Endometriosis, as chronic estrogen-dependent disease, is defined by the presence of endometrial-like tissue outside the uterus. Proliferation of endometrial tissue and neoangiogenesis are critical factors in development of endom…
Research questionDo human endometriosis organoids recapitulate aberrant progesterone signalling in the disease to serve as advanced experimental models for uncovering epigenetic mechanisms involved in attenuated progesterone response in end…
Abstract Study question Is epigenetic modifications pattern in DMR region of H19 gene different in endometrial tissues of women with endometriosis in compare to normal endometrium? Summary answer The methylation level in DMR region of H19 g…
Abstract Study question Evolution of the ALX1 and PDHX genes expression and incorporation of H2BK5ac mark on the promoter of these genes in endometriotic tissues versus normal endometrium Summary answer Lower incorporation of H2BK5ac mark i…
BackgroundThe 5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, which is expressed in human oocytes and preimplantation. Due to the involvement of MTHFR in female reproduction, we t…
Introduction: Endometriosis is a chronic inflammatory disease which affects fertility. This study was performed with aim to evaluate the clinical role of surgical intervention and assisted reproductive technology (ART) in infertile women wi…
Vitamin D is a fat-soluble vitamin that belongs to the family of steroid hormones. The biological actions of vitamin D are exerted through a soluble protein, the vitamin D receptor (VDR). VDR is a transcription factor located in the nuclei …