Hubert Thole

No ORCID on file · 8 papers in corpus · active 2006-2011

Study types

  • other 6
  • article 2

Condition tags

  • endometriosis 8
article 2011
Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2011.03.010

In the search for novel biomarkers of endometriosis, we selected 152 genes from the GeneLogic database based on results of genome-wide expression analysis of ovarian endometriosis, plus 20 genes related to estrogen metabolism and action. We…

other 2010
Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1
PloS one ·doi:10.1371/journal.pone.0010969

Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1) for the treatment of breast cancer or endometriosis, novel substa…

other 2009
Disturbed estrogen and progesterone action in ovarian endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.07.020

Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion. In the present study, we have examined the expression of 11 estrogen an…

other 2009
Estrone C15 derivatives--a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.10.022

Lowering local estradiol concentration by inhibition of the estradiol-synthesizing enzyme 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) has been proposed as a promising new therapeutic option to treat estrogen-dependent diseases …

other 2009
Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.09.024

17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the transformation of estrone (E1) into the most potent estrogen, estradiol (E2), which stimulates cell proliferation and decreases apoptosis. 17beta-HSD1 is often strongly …

other 2007
Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.1080/09513590601152219

Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites, and it is well known that endometriosis is an estrogen-dependent disease. The defective formation and metabolism of steroid hormones is res…

article 2007
Expression and regulation of estrogen-converting enzymes in ectopic human endometrial tissue
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.11.153

ObjectiveTo investigate the regulation of estrogen-converting enzymes in human ectopic endometrial tissue.DesignAnimal study.SettingAcademic medical center.Animal(s)Sixty female nude mice with implanted human endometrial tissue.Patient(s)Tw…

other 2006
New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2005.11.044

The estradiol-synthesizing enzyme 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) is mainly responsible for the conversion of estrone (E1) to the potent estrogen estradiol (E2). It is a key player to control tissue levels of E2 and …