Leena Hirvelä

No ORCID on file · 3 papers in corpus · active 2006-2010

Study types

  • other 3

Condition tags

  • endometriosis 3
other 2010
Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1
PloS one ·doi:10.1371/journal.pone.0010969

Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1) for the treatment of breast cancer or endometriosis, novel substa…

other 2009
Estrone C15 derivatives--a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.10.022

Lowering local estradiol concentration by inhibition of the estradiol-synthesizing enzyme 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) has been proposed as a promising new therapeutic option to treat estrogen-dependent diseases …

other 2006
New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2005.11.044

The estradiol-synthesizing enzyme 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) is mainly responsible for the conversion of estrone (E1) to the potent estrogen estradiol (E2). It is a key player to control tissue levels of E2 and …