Natasha L Orr

No ORCID on file · 40 papers in corpus · active 2017-2026

Study types

  • article 27
  • other 10
  • preprint 2
  • review 1

Condition tags

  • endometriosis 39
  • dyspareunia 20
  • chronic_pelvic_pain 9
  • die_deep_infiltrating 7
  • endometrioma 5
  • dysmenorrhea 4
  • infertility 3
  • adenomyosis 1
  • bowel_endometriosis 1
article 2021
Pain ·doi:10.1097/j.pain.0000000000002351

ABSTRACT: A key clinical problem is identifying the patient with endometriosis whose pain is complicated by central nervous system sensitization, where conventional gynecologic treatment (eg, hormonal therapy or surgery) may not completely …

other 2020
Journal of women's health (2002) ·doi:10.1089/jwh.2019.8008

Background: Endometriosis is a complex condition that can negatively affect a woman's quality of life, including her sleep. This study aims to assess the multifactorial variables associated with poorer quality of sleep in women with endomet…

article 2020
Sexual medicine ·doi:10.1016/j.esxm.2020.01.002

INTRODUCTION: Deep dyspareunia is a cardinal symptom of endometriosis, and as many as 40% of people with this condition experience comorbid superficial dyspareunia. AIM: To evaluate the relationship between sexual pain and infertility conce…

article 2020
The journal of sexual medicine ·doi:10.1016/j.jsxm.2019.12.019

INTRODUCTION: Deep dyspareunia, a common symptom in endometriosis, has previously been associated with bladder and/or pelvic floor tenderness (BPFT), which suggests a role for central nervous system sensitization. The Central Sensitization …

article 2019
·doi:10.1016/j.jsxm.2019.03.514

Deep dyspareunia affects 50% of women with endometriosis and has significant negative effects on relationships and sexual function. Previous research has identified painful bladder syndrome as a significant contributor to deep dyspareunia w…

review 2019
Sexual medicine reviews ·doi:10.1016/j.sxmr.2018.12.007

INTRODUCTION: Dyspareunia has been traditionally divided into superficial (introital) dyspareunia and deep dyspareunia (pain with deep penetration). While deep dyspareunia can coexist with a variety of conditions, recent work in endometrios…

article 2019
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC ·doi:10.1016/j.jogc.2019.08.034
article 2019
·doi:10.1016/j.jogc.2019.02.218
other 2019
PloS one ·doi:10.1371/journal.pone.0219064

PURPOSE: Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plas…

article 2018
·doi:10.1016/j.jsxm.2018.03.042

The etiology of endometriosis-associated deep dyspareunia (DD) may be due to direct disease-specific factors (e.g. location or invasiveness of disease) and/or to indirect contributors such as bladder/pelvic floor dysfunction. We aimed to de…

article 2018
·doi:10.14288/1.0365290

Endometriosis affects 10% of reproductive-aged women and is the presence of ectopic endometrial glands and stroma. It is associated with different types of pain, such as dysmenorrhea, dyschezia, and deep dyspareunia. Deep dyspareunia affect…

article 2018
The journal of sexual medicine ·doi:10.1016/j.jsxm.2018.06.007

INTRODUCTION: The etiology of endometriosis-associated deep dyspareunia may include direct endometriosis-specific factors (eg, stage or invasiveness of disease) and/or indirect contributors such as bladder/pelvic floor dysfunction (eg, rela…

article 2018
Human Reproduction ·doi:10.1093/humrep/dey332

STUDY QUESTION: Does incisional endometriosis (IE) harbor somatic cancer-driver mutations? SUMMARY ANSWER: We found that approximately one-quarter of IE cases harbor somatic-cancer mutations, which commonly affect components of the MAPK/RAS…

article 2018
·doi:10.1055/s-0038-1671405

Endometriosis is a common gynecological disease and precursor of clear cell and endometrioid ovarian carcinomas. We recently demonstrated that one form of endometriosis with little malignant potential, deep infiltrating endometriosis (DE), …

article 2017
The New England journal of medicine ·doi:10.1056/nejmoa1614814

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benig…