Yan D

No ORCID on file · 17 papers in corpus · active 2016-2026

Study types

  • article 9
  • other 2
  • review 1

Condition tags

  • endometriosis 12
  • adenomyosis 4
  • endometrioma 2
  • dysmenorrhea 1
  • chronic_pelvic_pain 1
other 2026
Human reproduction open ·doi:10.1093/hropen/hoag013

STUDY QUESTION: Does PIEZO1 play any role in adenomyosis-associated dysmenorrhea? SUMMARY ANSWER: PIEZO1 downregulation in the myometrium reduces the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, …

2025
BMJ open ·doi:10.1136/bmjopen-2024-096896

IntroductionTo assess the effects of oral dydrogesterone on the recurrence rate of endometrial polyps (EPs) and abnormal uterine bleeding (AUB) symptoms after transcervical resection of polyps (TCRP).Methods and analysisA randomised, parall…

2024
Molecular cancer ·doi:10.1186/s12943-024-02164-y

Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway, and the indole pathway. Under normal physiological conditions, Trp metabolism plays crucial r…

2024
Journal of epidemiology ·doi:10.2188/jea.je20230191

BackgroundCurrently, awareness about platelet count (PC) and its consequences for perinatal outcome have increased, but there is little reliable evidence on fecundability.MethodsBased on the National Free Pre-conception Check-up Projects su…

article 2023
Biomedicines ·doi:10.3390/biomedicines11102618

We investigated whether anogenital distance (AGD) is associated with adenomyosis, endometriosis and uterine leiomyomas (UL, also called uterine fibroids). We recruited 81 women with UL, 105 with ovarian endometrioma (OE), 116 with adenomyos…

other 2022
Toxicology ·doi:10.1016/j.tox.2021.153050

Emerging evidence suggests that excess iron accumulates in endometriotic and adenomyotic lesions. However, the role iron overload plays in the pathogenesis of endometriosis or adenomyosis remains unknown. Primary human eutopic endometrial s…

2022
Frontiers in pharmacology ·doi:10.3389/fphar.2022.962850

Objective: To explore the pharmacological basis and mechanism of Buxue Yimu pills (BYP) in the treatment of anaemia in women from the perspective of metabolomics and network analysis. Materials and Methods: Forty-six women of reproductive a…

2021
Cancer biology & therapy ·doi:10.1080/15384047.2021.1877864

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide. Emerging evidence has suggested that long noncoding RNAs (lncRNAs) play vital roles in various biological processes of cancers, such as cell proliferation…

article 2020
Reproduction (Cambridge, England) ·doi:10.1530/rep-20-0172

Indian hedgehog (Ihh) signaling regulates endometrial receptivity and is an indispensable mediator of embryonic implantation. Hedgehog signaling is known to regulate autophagy, and aberrant regulation of autophagy is critically implicated i…

article 2020
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgaa550

CONTEXT: While fibrosis in endometriosis has recently loomed prominently, the sources of myofibroblasts, the principal effector cell in fibrotic diseases, remain largely obscure. Mesothelial cells (MCs) can be converted into myofibroblasts …

article 2020
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.03.020

Research questionDo endometriotic lesions undergo endothelial-mesenchymal transition (EndoMT)?DesignLesion samples from 30 patients with ovarian endometriomas and deep endometriosis, and control endometrial tissue samples from 30 women with…

article 2020
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2020.04.006

Research questionDoes sodium tanshinone IIA sulfonate (STS) induce cellular senescence in endometriotic lesions and thus restrict lesional development and fibrogenesis in a recently established mouse model of deep endometriosis?DesignProspe…

article 2019
Scientific reports ·doi:10.1038/s41598-019-39170-w

Endometriotic lesions are known to be hyperinnervated, especially in lesions of deep endometriosis (DE), which are frequently in close proximity to various nerve plexuses. DE lesions typically have higher fibromuscular content than that of …

article 2018
Human Reproduction ·doi:10.1093/humrep/dey392

STUDY QUESTION: Do sensory nerves play any role in the development of endometriosis? SUMMARY ANSWER: Sensory nerves participate in all major steps (epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (F…

article 2018
Human Reproduction ·doi:10.1093/humrep/dey361

STUDY QUESTION: Is it possible to establish a mouse model of deep endometriosis (DE)? SUMMARY ANSWER: A mouse DE model that is macroscopically and microscopically similar to nodular lesions in humans can be constructed in as short as 3 week…

article 2016
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719116670037

Hyperinnervation in endometriosis is now well documented, but so far only a few neurotrophins have been identified. Since endometriotic stromal cells secrete thromboxane A2 (TXA2), we sought to determine whether TXA2, derived from endometri…

review 2016
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2016.06.017

One of major objectives in treating endometriosis is to alleviate pain since dysmenorrhea and other types of pain top the list of complaints from women with endometriosis who seek medical attention. Indeed, endometriosis-associated pain (EA…