Gu H

No ORCID on file · 21 papers in corpus · active 2016-2026

Study types

  • article 2
  • other 1

Condition tags

  • endometriosis 3
  • infertility 1
  • die_deep_infiltrating 1
2026
Cell genomics ·doi:10.1016/j.xgen.2025.101012

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

article 2025
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2025.114607

OBJECTIVES: To investigate the clinical characteristics of deep infiltrating endometriosis (DIE), summarize the experiences in its diagnosis and management, and identify potential peripheral blood indicators associated with the severity of …

2025
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-025-01406-y

BackgroundWhile the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an atla…

2025
Frontiers in endocrinology ·doi:10.3389/fendo.2025.1705636

ObjectiveWe aimed to analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR), and the treatment outcomes for infertile women after in vitro fertilization (IVF) using embryo transfer technology.MethodsThis retrospective stud…

2025
Acta pharmaceutica Sinica. B ·doi:10.1016/j.apsb.2025.02.007

As the most abundant and essential structural protein in the human body, collagen is ubiquitously present in the interstitium of nearly all solid organs, playing a crucial role in maintaining the structural integrity and functional stabilit…

2024
BMC pregnancy and childbirth ·doi:10.1186/s12884-023-06210-3

BackgroundPolycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disease in women. Hyperandrogenaemia (HA) and insulin resistance (IR) are the basic pathophysiological characteristics of PCOS. The aetiology of PCOS has not b…

2024
American journal of translational research ·doi:10.62347/ecoo9552

BackgroundEvidence indicates that the risk of developing a secondary ovarian cancer (OC) is correlated with estrogen receptor (ER) status. However, the clinical significance of the relationship between ER-associated breast cancer (BC) and c…

other 2024
Genes & genomics ·doi:10.1007/s13258-024-01497-8

BACKGROUND: Patients of ovary endometriosis have an abnormal immune micro-environment, leading to endometrial tissue that from retrograde menstruation evade immune surveillance and subsequently develop into ectopic lesions. OBJECTIVE: This…

2024
Clinical and translational medicine ·doi:10.1002/ctm2.1644

RNA methylation is widespread in nature. Abnormal expression of proteins associated with RNA methylation is strongly associated with a number of human diseases including cancer. Increasing evidence suggests that targeting RNA methylation ho…

2024
Frontiers in immunology ·doi:10.3389/fimmu.2024.1464474

BackgroundBullous pemphigoid (BP) is a rare, life-threatening autoimmune blistering disease with pruritus and tension blisters/bullous as the main clinical manifestations. Glucocorticosteroids are the main therapeutic agents for it, but the…

article 2023
iScience ·doi:10.1016/j.isci.2023.108158

Endometriosis (EMS) is a prevalent disease and the etiologies has not uniform. Microbiota is associated with human diseases. To delve into the relationship between EMS and microbiota, Ectopic (EM) and eutopic (EU) endometrial tissues, phary…

2023
Open life sciences ·doi:10.1515/biol-2022-0670

This study aimed to investigate effects of pulmonary fractalkine (FKN/CX3CL1) on angiogenesis and tube formation. Tube forming capability of pulmonary vascular endothelial cells (PVECs) was evaluated. CCK-8 assay was used to evaluate prolif…

2023
Scientific reports ·doi:10.1038/s41598-023-35655-x

The objective of this study is to develop a gene signature related to the immune system that can be used to create personalized immunotherapy for Uterine Corpus Endometrial Carcinoma (UCEC). To classify the UCEC samples into different immun…

2023
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1129657

BackgroundPremature ovarian insufficiency (POI) is one of the most common causes of female infertility and the etiology is highly heterogeneous. Most cases are idiopathic and the pathogenesis remains unclear. Previous studies proved that th…

2022
Molecules (Basel, Switzerland) ·doi:10.3390/molecules27103082

Mono-(2-ethylhexyl) phthalate (MEHP) is one of the main active metabolites of di-(2-ethylhexyl) phthalate (DEHP). In our previous works, by using rat and Drosophila models, we showed a disruption of neural function due to DEHP. However, the…

2021
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-020-01943-y

ObjectiveTo study the effect of aging on ovarian circadian rhythm.DesignHuman and animal study.SettingUniversity hospital and research laboratory.Patients/animalsHuman granulosa cells were obtained by follicular aspiration from women underg…

2021
Frontiers in oncology ·doi:10.3389/fonc.2021.608999

ObjectiveTo evaluate the value of routine preoperative gastroscopy/colonoscopy in patients with suspected ovarian cancer for differential diagnosis and judgment of bowel resection.MethodsAll women diagnosed with suspected ovarian cancer who…

2021
Molecules (Basel, Switzerland) ·doi:10.3390/molecules26195931

Acute kidney injury (AKI) is a dose-limiting side effect of cisplatin therapy in cancer patients. However, effective therapies for cisplatin-induced AKI are not available. Oxidative stress, tubular cell death, and inflammation are known to …

2020
Scientific reports ·doi:10.1038/s41598-020-67750-8

Circular RNAs (circRNAs) serve as competing endogenous RNAs (ceRNAs) and indirectly regulate gene expression through shared microRNAs (miRNAs). However, the potential circRNAs functioning as ceRNAs in osteoporosis remain unclear. The bone m…

2017
American journal of translational research

The aim of this study was to identify specific microRNAs (miRNAs) and their regulatory roles in the process of 1, 25-dihydroxyvitamin D3-induced (VD3-induced) osteogenic differentiation of human adipose-derived Mesenchymal stem cells (hAMSC…

2016
Scientific reports ·doi:10.1038/srep19825

MicroRNA plays an important role in spermatogenesis. Whether pre-miRNAs polymorphisms are associated with idiopathic male infertility remains obscure. In this study, 1378 idiopathic infertile males and 486 fertile controls were included bet…