Sang Q

No ORCID on file · 3 papers in corpus · active 2024-2026
2026
CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.
EMBO molecular medicine ·doi:10.1038/s44321-026-00448-y

Precise regulation of alternative splicing (AS) of maternal mRNAs is crucial for maintaining mRNA homeostasis and for acquiring oocyte competence. However, the regulatory factors and mechanisms of AS regulating oocyte competence and human f…

2026
Genetic landscape of human oocyte/embryo defects.
Cell genomics ·doi:10.1016/j.xgen.2025.101012

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

2024
Polyphyllin I alleviates neuroinflammation after cerebral ischemia-reperfusion injury via facilitating autophagy-mediated M2 microglial polarization.
Molecular medicine (Cambridge, Mass.) ·doi:10.1186/s10020-024-00828-5

Microglial activation and polarization play a central role in poststroke inflammation and neuronal damage. Modulating microglial polarization from pro-inflammatory to anti-inflammatory phenotype is a promising therapeutic strategy for the t…