Michel Canis

ObjectiveThis study was undertaken to evaluate the immunohistochemical expression of the cell cycle inhibitor p27Kip1 and proliferation marker Ki67 in peritoneal endometriosis and eutopic endometrium.DesignProspective study.SettingUniversit…

ObjectiveTo investigate the angiogenic status of the vasculature in peritoneal endometriosis based on macroscopic appearance.DesignProspective study.SettingUniversity hospital.Patient(s)Patients with peritoneal endometriosis.Intervention(s)…

BACKGROUND: Ovarian response during IVF cycles after laparoscopic ovarian cystectomy for endometriotic cysts >3 cm is controversial. A retrospective study was designed to study this problem. METHODS: At laparoscopy, endometriomas >3 cm were…

Adenomyosis keeps a strange and unknown feature. Indeed, therefore of an unclear physiopathology, the difficult diagnosis due to the lack of specificity of symptoms and the absence of effective conservative treatment, adenomyosis is still t…

OBJECTIVE: To evaluate the degree of fibrosis in the stroma of peritoneal endometriosis, according to the macroscopic appearance. METHODS: Red and black lesions of peritoneal endometriosis were collected and type-I collagen was immunohistoc…

Wide inter-individual variation of expression of compound metabolic enzymes is determined by polymorphism and may predispose the development of diseases provoked by environmental factors. The combined analysis of phase II detoxification sys…

We evaluated angiogenesis in eutopic endometrium and ectopic endometrium from patients with endometriosis. Microvessels were identified by immunohistochemistry using anti-von-Willebrand factor antibody and vascular parameters were measured …

PROBLEM: Factors regulating fibrosis in peritoneal endometriosis are poorly understood. We hypothesized that mast cell proteases may play a role in the process of fibrosis in peritoneal endometriosis. As the first step in examining the poss…

A human epithelial-like cell line derived from peritoneal implants from a patient with gonadotrophin-releasing hormone (GnRH) agonist-resistant endometriosis graded as stage IVd according to the American Fertility Society classification was…

ObjectiveTo estimate the empirical relationship between the revised American Society for Reproductive Medicine's classification of endometriosis and pregnancy rates after treatment.DesignRetrospective analysis.Patient(s)Patients seen by fou…

Colo-rectal endometriosis requiring colon resection are reported in 8 patients to illustrated the diagnostic and therapeutic problems encountered in the management of this uncommon localisation. Pericatamenial or catamenial bowel symptoms a…

Using technological progress, laparoscopic lymphadenectomy is becoming the standard for staging of pelvic cancer. In the same way more extensive procedures such as para-aortic lymph nodes dissection and radical hysterectomy have been demons…

From their experience and from data in the literature, the authors try to define the respective place of the different treatments for endometriosis, especially those of operative laparoscopy. In cases of endometriosis-associated infertility…

From January 1989 to December 1990, 196 patients were treated by hysteroscopic endometrial resection for abnormal uterine bleeding. A survey in February 1993 revealed a satisfaction rate of 82%. Persistence of abnormal bleeding after resect…

OBJECTIVE: Study of factors affecting risk of failure after hysteroscopic endometrial resection. METHODOLOGY: A retrospective study of 196 patients treated by hysteroscopic endometrial resection for abnormal uterine bleeding from January 19…

A perfect endometriosis classification should be a common language and an expert system which helps the gynaecologist to decide the treatment of each patient. The staging of endometriosis is not a new idea; the first classification based on…

Thirty-three patients were selected for laparoscopic hysterectomy and operated on in the Department of Obstetrics, Gynecology and Reproductive Medicine of Clermont-Ferrand University Hospital. Surgical techniques included blunt dissection w…

Laparoscopic hysterectomy is a recent procedure. We present our preliminary results about 44 patients. In 77.3% of cases (34 patients) the operation was carried out completely by laparoscopy and 10 patients (22.7%) required conversion of th…

Forty-two patients who underwent a second-look laparoscopy after a unilateral or bilateral intraperitoneal cystectomy for treatment of an ovarian endometrioma of greater than 3 cm were included. At second-look laparoscopy, 92.4% of the adne…

Benign ovarian cysts can be diagnosed and treated by surgical laparoscopy which, like laparotomy, permits a histological examination. Ovarian cysts that are, or are suspected of being malignant must be removed by laparotomy after evaluation…