Qian K

No ORCID on file · 9 papers in corpus · active 2008-2026
2026
Phase 1 dose-escalation trial of sub-endometrial injection of human embryonic stem cells-derived immunity-and-matrix-regulatory cells to promote endometrial angiogenesis in refractory intrauterine adhesion.
Molecular therapy : the journal of the American Society of Gene Therapy ·doi:10.1016/j.ymthe.2025.09.035

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

2025
Correlation between the follicular fluid extracellular-vesicle-derived microRNAs and signaling disturbance in the oocytes of women with polycystic ovary syndrome.
Journal of ovarian research ·doi:10.1186/s13048-025-01619-0

Polycystic ovary syndrome (PCOS) is a common reproductive disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. The quality of oocytes in PCOS patients remains poor, leading to poor pregnancy outcomes. T…

2025
Identification of potential therapeutic targeting in ovarian aging from genetic screening with clinical validation.
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-025-03490-w

PurposeTo screen drug targets of ovarian aging from a genetic perspective.MethodsSystematic analyses were conducted with cis-expression quantitative trait loci data of druggable genes extracted as instrument variables. Summary statistics we…

2025
PLGA-Based Co-Delivery Nanoformulations: Overview, Strategies, and Recent Advances.
Pharmaceutics ·doi:10.3390/pharmaceutics17121613

Poly (lactic-co-glycolic acid) (PLGA) is a widely used copolymer with applications across medical, pharmaceutical, and other industrial fields. Its biodegradability and biocompatibility make it one of the most versatile polymers for nanosca…

2025
Pregnancy and obstetric-neonatal outcomes of patients with thin endometrium using three different endometrial preparation protocols in frozen embryo transfer cycles: a historical cohort of 2671 patients.
Reproductive health ·doi:10.1186/s12978-025-02166-z

BACKGROUND: Endometrial thickness independently predicts pregnancy outcomes in frozen embryo transfer (FET) cycles. Thin endometrium always results in implantation failure and worse obstetric-neonatal outcomes. However, it has not been repo…

2023
Nomogram for predicting the risk of preterm delivery after IVF/ICSI treatment: an analysis of 11513 singleton births.
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1065291

BackgroundThere is a higher risk of preterm delivery (PTD) in singleton live births conceived after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) compared with spontaneously conceived pregnancies. The objective of our…

2023
Young women were associated with higher risk of hypertensive disorders of pregnancy and cesarean section from hormone replaced cycles in frozen-thawed embryo transfer: a retrospective study of 5316 singleton deliveries.
Frontiers in endocrinology ·doi:10.3389/fendo.2023.1238887

BackgroundThe utilization of frozen-thawed embryo transfer (FET) cycles has been linked to heightened risks of adverse perinatal outcomes. However, the potential association between adverse perinatal outcomes and distinct endometrial prepar…

2021
The Effect of Endometrial Thickness on Pregnancy, Maternal, and Perinatal Outcomes of Women in Fresh Cycles After IVF/ICSI: A Systematic Review and Meta-Analysis.
Frontiers in endocrinology ·doi:10.3389/fendo.2021.814648

BackgroundThin endometrium on ovulation triggering day is associated with impaired pregnancy outcomes in women after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), but the role of thick endometrium on pregnancy outcomes…

2008
Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/den082

BackgroundThe HOXA10 homeobox gene controls embryonic uterine development and adult endometrial receptivity. The three-amino-acid loop extension (TALE) family homeobox genes like myeloid ecotropic viral integration site 1 (MEIS) provide enh…